ArticleMolecules (Basel, Switzerland)2019
Fiber-Array-Based Raman Hyperspectral Imaging for Simultaneous, Chemically-Selective Monitoring of Particle Size and Shape of Active Ingredients in Analgesic Tablets.
Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Determination of Particle Size of Active Pharmaceutical Ingredients in Dry Powder Inhaler Formulations.Pharmaceuticals (Basel, Switzerland) · 2026Article
- A review of research methods for elucidating the microstructure of pharmaceutical preparations.Journal of pharmaceutical analysis · 2025Review
- Impact of clinical preparation steps and use of sex-specific reference for accurate antibiotic monitoring in body fluids.Communications medicine · 2025Article
- The Role of Hydrogen Bonding in the Raman Spectral Signals of Caffeine in Aqueous Solution.Molecules (Basel, Switzerland) · 2024Article
- Spectrally Resolved and Highly Parallelized Raman Difference Spectroscopy for the Analysis of Drug-Target Interactions between the Antimalarial Drug Chloroquine and Hematin.Analytical chemistry · 2024Article
- Isotopomeric Peak Assignment for NAnalytical chemistry · 2024Article
- Molecular Interactions Identified by Two-Dimensional Analysis-Detailed Insight into the Molecular Interactions of the Antimalarial Artesunate with the Target Structure β-Hematin by Means of 2D Raman Correlation Spectroscopy.Analytical chemistry · 2023Article
- Investigations on the Novel Antimalarial Ferroquine in Biomimetic Solutions Using Deep UV Resonance Raman Spectroscopy and Density Functional Theory.Analytical chemistry · 2023Article
- Parallelized Raman Difference Spectroscopy for the Investigation of Chemical Interactions.Analytical chemistry · 2022Article
- Measuring Bismuth Oxide Particle Size and Morphology in Film-Coated Tablets.Molecules (Basel, Switzerland) · 2022Article
- A Review of Pharmaceutical Robot based on Hyperspectral Technology.Journal of intelligent & robotic systems · 2022Review
- In Vitro Tests of FDM 3D-Printed Diclofenac Sodium-Containing Implants.Molecules (Basel, Switzerland) · 2020Article
- Rapid Raman Spectroscopic Analysis of Stress Induced Degradation of the Pharmaceutical Drug Tetracycline.Molecules (Basel, Switzerland) · 2020Article
- Highly Sensitive Detection of the Antibiotic Ciprofloxacin by Means of Fiber Enhanced Raman Spectroscopy.Molecules (Basel, Switzerland) · 2019Article
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Authors and funding
5 authors.
Funding
Abstract
The particle shape, size and distribution of active pharmaceutical ingredients (API) are relevant quality indicators of pharmaceutical tablets due to their high impact on the manufacturing process. Furthermore, the bioavailability of the APIs from the dosage form depends largely on these characteristics. Routinely, particle size and shape are only analyzed in the powder form, without regard to the effect of the formulation procedure on the particle characteristics. The monitoring of these parameters improves the understanding of the process; therefore, higher quality and better control over the biopharmaceutical profile can be ensured. A new fiber-array-based Raman hyperspectral imaging technique is presented for direct simultaneous in-situ monitoring of three different active pharmaceutical ingredients- acetylsalicylic acid, acetaminophen and caffeine- in analgesic tablets. This novel method enables a chemically selective, noninvasive assessment of the distribution of the active ingredients down to 1 µm spatial resolution. The occurrence of spherical and needle-like particles, as well as agglomerations and the respective particle size ranges, were rapidly determined for two commercially available analgesic tablet types. Subtle differences were observed in comparison between these two tablets. Higher amounts of acetaminophen were visible, more needle-shaped and bigger acetylsalicylic acid particles, and a higher incidence of bigger agglomerations were found in one of the analgesic tablets.
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