ArticleInternational journal of molecular sciences2019
Gonadotropin Releasing Hormone Agonists Have an Anti-apoptotic Effect on Cumulus Cells.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Ovarian tissue cryopreservation for fertility preservation: a two-decade single-center experience with 451 children and adolescents.Reproductive biology and endocrinology : RB&E · 2025Article
- Gonadotropin Activity during Early Folliculogenesis and Implications for Polycystic Ovarian Syndrome and Premature Ovarian Insufficiency: A Narrative Review.International journal of molecular sciences · 2024Review
- Long-acting gonadotropin-releasing hormone agonist trigger in fertility preservation cycles before chemotherapy.ESMO open · 2023Article
- Ovarian protection and safety of gonadotropin-releasing hormone agonist after cervical cancer surgery: systematic review and meta-analysis.Annals of translational medicine · 2022Article
- GnRH Analogues as a Co-Treatment to Therapy in Women of Reproductive Age with Cancer and Fertility Preservation.International journal of molecular sciences · 2022Review
- The effects and mechanism of taxanes on chemotherapy-associated ovarian damage: A review of current evidence.Frontiers in endocrinology · 2022Review
- GnRHa protects the ovarian reserve by reducing endoplasmic reticulum stress during cyclophosphamide-based chemotherapy.NPJ breast cancer · 2021Article
- How to Protect Ovarian Function before and during Chemotherapy?Journal of clinical medicine · 2021Review
- The role of gonadotropin-releasing hormone agonists in female fertility preservation.Clinical and experimental reproductive medicine · 2021Article
- Gender-specific aspects related to type of fertility preservation strategies and access to fertility care.ESMO open · 2020Review
- Burning Questions in the Oncofertility Counseling of Young Breast Cancer Patients.Breast cancer : basic and clinical research · 2020Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundOvaries are sensitive to chemotherapy, which may lead to early depletion of primordial follicle reserve. One strategy for gonadal function preservation is temporary ovarian suppression with Gonadotropin Releasing Hormone agonists (GnRHa) during chemotherapy. To date, GnRHa protective mechanism of action remains not fully elucidated.
methodsWe collected 260 immature cumulus cell-oocyte complexes (COC) from 111 women < 38 years old, with a normal ovarian reserve. The COC were randomly assigned to the following groups: a) control; culture with the addition of b) GnRHa; c) cyclophosphamide; d) cyclophosphamide plus GnRHa. After in vitro treatments, RNA and proteins were extracted from oocytes and cumulus cells (CC), separately. Potential effects of drugs were evaluated on GnRH receptors, apoptosis pathways, ceramide pathway, and glutathione synthesis by quantitative PCR and, whenever possible, by Western blot.
resultsCyclophosphamide triggered activation of the extrinsic pathway of apoptosis mediated by BAX in CC. The co-administration of GnRHa inhibited the apoptosis pathway in CC. According to our model, the GnRHa does not directly act on oocytes, which do not express GnRH receptors. Moreover, glutathione synthesis was decreased after GnRHa treatment both in CC and oocytes.
conclusionOur data suggest that the protective mechanisms induced by GnRHa is mediated by an anti-apoptotic effect on CC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.