Evidence map›Paper›PMID 31801218›Full record

ArticleInternational journal of molecular sciences2019

Whole Genome Expression Analyses of miRNAs and mRNAs Suggest the Involvement of miR-320a and miR-155-3p and their Targeted Genes in Lithium Response in Bipolar Disorder.

Claudia Pisanu, Eleni Merkouri Papadima, Carla Melis, Donatella Congiu, Annalisa Loizedda, Nicola Orrù, Stefano Calza, Sandro Orrù, Carlo Carcassi, Giovanni Severino and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

  1. The Regulatory Potential of Long Non-Coding RNAs in Bipolar Disorder.International journal of molecular sciences · 2026
    Review
  2. Genetic underpinnings of YMRS and MADRS scores variations in a bipolar sample.European archives of psychiatry and clinical neuroscience · 2026
    Article
  3. Article
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  5. Review
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  8. RNA Biomarkers in Bipolar Disorder and Response to Mood Stabilizers.International journal of molecular sciences · 2023
    Review
  9. Article
  10. Article
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  12. Article
  13. Review
  14. Review
  15. Genetic and Epigenetic Markers of Lithium Response.International journal of molecular sciences · 2022
    Review
  16. Article
  17. Article
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Claudia PisanuDepartment of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato, 09042 Cagliari, Italy.ORCID 0000-0002-9151-4319
Eleni Merkouri PapadimaDepartment of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato, 09042 Cagliari, Italy.
Carla MelisDepartment of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato, 09042 Cagliari, Italy.
Donatella CongiuDepartment of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato, 09042 Cagliari, Italy.
Annalisa LoizeddaConsiglio Nazionale delle Ricerche (C.n.R.), Istituto di Ricerca Genetica e Biomedica (I.R.G.B.), Monserrato, 09042 Cagliari, Italy.
Nicola OrrùMedical Genetics, R. Binaghi Hospital, ASSL Cagliari, ATS Sardegna, 09021 Cagliari, Italy.
Stefano CalzaUnit of Biostatistics and Bioinformatics, Department of Molecular and Translational Medicine, University of Brescia, 25121 Brescia, Italy.ORCID 0000-0003-4996-7995
Sandro OrrùMedical Genetics, R. Binaghi Hospital, ASSL Cagliari, ATS Sardegna, 09021 Cagliari, Italy.
Carlo CarcassiMedical Genetics, R. Binaghi Hospital, ASSL Cagliari, ATS Sardegna, 09021 Cagliari, Italy.ORCID 0000-0002-9533-1579
Giovanni SeverinoDepartment of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato, 09042 Cagliari, Italy.
Raffaella ArdauUnit of Clinical Pharmacology of the University Hospital of Cagliari, 09042 Cagliari, Italy.
Caterina ChillottiUnit of Clinical Pharmacology of the University Hospital of Cagliari, 09042 Cagliari, Italy.
Maria Del ZompoDepartment of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato, 09042 Cagliari, Italy.ORCID 0000-0001-9491-5938
Alessio SquassinaDepartment of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato, 09042 Cagliari, Italy.ORCID 0000-0001-7415-7607
University of Cagliari · ITATS Sardegna (Italy) · ITInstitute of Genetic and Biomedical Research · ITUniversity of Brescia · IT

Funding

Fondazione Umberto Veronesi FellowshipFondo integrativo per la ricerca (Fir) Annualità 2018Regione Autonoma della Sardegna", L.R. 7, 2007, 2013 call. Project ID: CRP-79506 a
6 · The paper itself

Abstract

Lithium is the mainstay in the maintenance of bipolar disorder (BD) and the most efficacious pharmacological treatment in suicide prevention. Nevertheless, its use is hampered by a high interindividual variability and important side effects. Genetic and epigenetic factors have been suggested to modulate lithium response, but findings so far have not allowed identifying molecular targets with predictive value. In this study we used next generation sequencing to measure genome-wide miRNA expression in lymphoblastoid cell lines from BD patients excellent responders (ER,

Indexed as

AdultBipolar DisorderCalpainCell LineFemaleGene Expression ProfilingGene Expression RegulationGenome, HumanHumansLithiumLymphocytesMaleMicroRNAsMiddle AgedOligonucleotide Array Sequence AnalysisPrimary Cell CultureCalpainCAPNS1 protein, humanLithiumMicroRNAsMIRN155 microRNA, humanMIRN320 microRNA, humanPsychotropic DrugsRGS16 proteinRGS ProteinsRNA, MessengerSP4 protein, humanSp4 Transcription FactorepigeneticsmicroRNAmiRNAmood disordersmood stabilizersnext generation sequencingpharmacogenetics

Identifiers

PMID31801218
PMCPMC6928759
OpenAlexW2990169034

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.