Evidence map›Paper›PMID 31801190›Full record

ArticleMolecules (Basel, Switzerland)2019

Green Synthesis and Electrochemical Properties of Mono- and Dimers Derived from Phenylaminoisoquinolinequinones.

Juana Andrea Ibacache, Jaime A Valderrama, Judith Faúndes, Alex Danimann, Francisco J Recio, César A Zúñiga

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. New 2-Acetyl-3-aminophenyl-1,4-naphthoquinones: Synthesis andOxidative medicine and cellular longevity · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Juana Andrea IbacacheFacultad de Química y Biología, Universidad de Santiago de Chile, Alameda 3363, casilla 40, Santiago 9170022, Chile.
Jaime A ValderramaFacultad de Ciencias de la Salud, Universidad Arturo Prat, casilla 121, Iquique 1100000, Chile.
Judith FaúndesFacultad de Química y Biología, Universidad de Santiago de Chile, Alameda 3363, casilla 40, Santiago 9170022, Chile.
Alex DanimannFacultad de Química y Biología, Universidad de Santiago de Chile, Alameda 3363, casilla 40, Santiago 9170022, Chile.
Francisco J RecioFacultad de Química y Farmacia, Universidad Católica de Chile, casilla 306, Santiago 7820436, Chile.ORCID 0000-0002-5181-3197
César A ZúñigaFacultad de Química y Farmacia, Universidad Católica de Chile, casilla 306, Santiago 7820436, Chile.ORCID 0000-0002-0894-3383

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the search for new quinoid compounds endowed with potential anticancer activity, the synthesis of novel heterodimers containing the cytotoxic 7-phenylaminoisoquinolinequinone and 2-phenylaminonaphthoquinone pharmacophores, connected through methylene and ethylene spacers, is reported. The heterodimers were prepared from their respective isoquinoline and naphthoquinones and 4,4'-diaminodiphenyl alkenes. The access to the target heterodimers and their corresponding monomers was performed both through oxidative amination reactions assisted by ultrasound and CeCl

Indexed as

Chemical PhenomenaChemistry Techniques, SyntheticGreen Chemistry TechnologyAniline CompoundsAntineoplastic AgentsCell Line, TumorElectrochemistryHumansIsoquinolinesMolecular StructurePolymersAniline CompoundsAntineoplastic AgentsIsoquinolinesPolymersamination reactioncyclic voltammetrygreen synthesishalf-wave potentialheterodimerstwin drugs

Identifiers

PMID31801190
PMCPMC6930604

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.