ArticleCell reports2019
Identification of Neuronal Lineages in the Drosophila Peripheral Nervous System with a "Digital" Multi-spectral Lineage Tracing System.
Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Intensity modulation of trichromatic split fluorescent proteins for live cell mapping.Cell reports methods · 2026Article
- Inferring cell differentiation maps from lineage tracing data.Nature methods · 2026Article
- Automated neuronal reconstruction with super-multicolour Tetbow labelling and threshold-based clustering of colour hues.Nature communications · 2024Article
- Input density tunes Kenyon cell sensory responses in the Drosophila mushroom body.Current biology : CB · 2023Article
- Hacking brain development to test models of sensory coding.bioRxiv : the preprint server for biology · 2023Article
- Systematic expression profiling of Dpr and DIP genes reveals cell surface codes in Drosophila larval motor and sensory neurons.Development (Cambridge, England) · 2022Article
- Blind demixing methods for recovering dense neuronal morphology from barcode imaging data.PLoS computational biology · 2022Article
- Principles for the design of multicellular engineered living systems.APL bioengineering · 2022Article
- Multicolor strategies for investigating clonal expansion and tissue plasticity.Cellular and molecular life sciences : CMLS · 2022Review
- The molecular landscape of neural differentiation in the developing Drosophila brain revealed by targeted scRNA-seq and multi-informatic analysis.Cell reports · 2021Article
- Deciphering neural heterogeneity through cell lineage tracing.Cellular and molecular life sciences : CMLS · 2021Review
- Bitbow Enables Highly Efficient Neuronal Lineage Tracing and Morphology Reconstruction in SingleFrontiers in neural circuits · 2021Article
- Light microscopy based approach for mapping connectivity with molecular specificity.Nature communications · 2020Article
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Authors and funding
8 authors.
Funding
Abstract
Elucidating cell lineages provides crucial understanding of development. Recently developed sequencing-based techniques enhance the scale of lineage tracing but eliminate the spatial information offered by conventional approaches. Multi-spectral labeling techniques, such as Brainbow, have the potential to identify lineage-related cells in situ. Here, we report nuclear Bitbow (nBitbow), a "digital" version of Brainbow that greatly expands the color diversity for scoring cells, and a suite of statistical methods for quantifying the lineage relationship of any two cells. Applying these tools to the Drosophila peripheral nervous system (PNS), we determined lineage relationship between all neuronal pairs. This study demonstrates nBitbow as an efficient tool for in situ lineage mapping, and the complete lineage relationship among larval PNS neurons opens new possibilities for studying how neurons gain specific features and circuit connectivity.
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