Evidence map›Paper›PMID 31800450›Full record

ArticleJournal of occupational and environmental medicine2019

Analysis of Postdeployment Serum Samples Identifies Potential Biomarkers of Exposure to Burn Pits and Other Environmental Hazards.

Thomas H Thatcher, Collynn F Woeller, Juilee Thakar, Atif Khan, Philip K Hopke, Matthew Ryan Smith, Karan Uppal, Douglas I Walker, Young-Mi Go, Dean P Jones and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of occupational and environmental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Metabolomics and proteomics in occupational medicine: a comprehensive systematic review.Journal of occupational medicine and toxicology (London, England) · 2024
    Review
  4. Article
  5. Military burn pit exposure and airway disease: Implications for our Veteran population.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2023
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Thomas H ThatcherDepartment of Medicine, University of Rochester Medical Center, Rochester, New York (Dr Thatcher, Dr Sime, Dr Phipps, and Dr Utell); Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York (Dr Woeller, Dr Sime, Dr Phipps, and Dr Utell); Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York (Dr Thakar, Dr Khan, Dr Sime, and Dr Phipps); Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York (Dr Thakar and Dr Khan); Department of Public Health Sciences, University of Rochester Medical Center, Rochester, New York (Dr Hopke); Center for Air Resources Engineering and Science, Clarkson University, Potsdam, New York (Dr Hopke); Clinical Biomarkers Laboratory, Division of Pulmonary Medicine, Department of Medicine, Emory University, Atlanta, Georgia (Dr Smith, Dr Uppal, Dr Walker, Dr Go, and Dr Jones); Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York (Dr Walker); Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland (Dr Krahl and Dr Mallon); Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia (Dr Thatcher and Dr Sime).
Collynn F Woeller
Juilee Thakar
Atif Khan
Philip K Hopke
Matthew Ryan Smith
Karan Uppal
Douglas I Walker
Young-Mi Go
Dean P Jones
Pamela L Krahl
Timothy M Mallon
Patricia J Sime
Richard P Phipps
Mark J Utell

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Sally W Thurston · 1985 to 2026
$42.8M
MULTIDISCIPLINARY TRAINING IN PULMONARY RESEARCHT32HL066988 · NHLBI · UNIVERSITY OF ROCHESTER · PI GEORAS, STEVE N, O'REILLY, MICHAEL A · 2001 to 2021
$8.1M
NHLBI NIH HHS T32 HL066988NIEHS NIH HHS P30 ES001247
6 · The paper itself

Abstract

objectiveThe potential health risks of deployment to sites with open burn pits remain poorly understood, in part, because personal exposure monitoring was not performed. Here, we investigated whether postdeployment serum samples contain biomarkers associated with exposure to burn pits.

methodsA total of 237 biomarkers were measured in 800 serum samples from deployed and never-deployed subjects. We used a regression model and a supervised vector machine to identify serum biomarkers with significant associations with exposures and deployment.

resultsWe identified 101 serum biomarkers associated with polycyclic aromatic hydrocarbons, dioxins or furans, and 54 biomarkers associated with deployment. Twenty-six of these biomarkers were shared in common by the exposure and deployment groups.

conclusionsWe identify a potential signature of exposure to open burn pits, and provide a framework for using postexposure sera to identify exposures when contemporaneous monitoring was inadequate.

Indexed as

Afghan Campaign 2001-Air PollutantsBiomarkersDioxinsFemaleFuransHumansIncinerationInhalation ExposureIraq War, 2003-2011Machine LearningMaleMass SpectrometryMicroRNAsMilitary PersonnelPolycyclic Aromatic HydrocarbonsAir PollutantsBiomarkersDioxinsFuransMicroRNAsPolycyclic Aromatic Hydrocarbons

Identifiers

PMID31800450
PMCPMC6901100

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.