Evidence map›Paper›PMID 31800447›Full record

ArticleJournal of occupational and environmental medicine2019

Environmental Chemicals Altered in Association With Deployment for High Risk Areas.

Matthew Ryan Smith, Karan Uppal, Douglas I Walker, Mark J Utell, Philip K Hopke, Timothy M Mallon, Pamela L Krahl, Patricia Rohrbeck, Young-Mi Go, Dean P Jones

Abstract read
In one paragraph

Article in Journal of occupational and environmental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Metabolome-Wide Association Study of Deployment to Balad, Iraq or Bagram, Afghanistan.Journal of occupational and environmental medicine · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Matthew Ryan SmithClinical Biomarkers Laboratory, Division of Pulmonary Medicine, Department of Medicine, Emory University, Atlanta, Georgia (Dr Smith, Dr Uppal, Dr Walker, Dr Go, Dr Jones); Department of Environmental Medicine (Dr Utell); Pulmonary Division, Department of Medicine (Dr Utell); Department of Public Health Sciences (Dr Hopke), University of Rochester Medical Center, Rochester, New York ; Uniformed Services University of the Health Sciences, Department of Preventive Medicine & Biostatistics, F. Edward Hébert School of Medicine, Bethesda (Dr Mallon, Dr Krahl); Armed Forces Health Surveillance Center, Silver Spring (Ms Rohrbeck), Maryland.
Karan Uppal
Douglas I Walker
Mark J Utell
Philip K Hopke
Timothy M Mallon
Pamela L Krahl
Patricia Rohrbeck
Young-Mi Go
Dean P Jones

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Sally W Thurston · 1985 to 2026
$42.8M
Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI William Michael Caudle · 2013 to 2026
$22.6M
Cytoplasmic-nuclear redox signaling: Disruption by dietary cadmium levelsR01ES023485 · NIEHS · EMORY UNIVERSITY · PI GO KANG, YOUNG-MI, JONES, DEAN PAUL · 2014 to 2018
$1.8M
Orbitrap Elite/H-ESI BundleS10OD018006 · OD · EMORY UNIVERSITY · PI JONES, DEAN PAUL · 2014 to 2014
$600k
NIEHS NIH HHS P30 ES001247NIEHS NIH HHS P30 ES019776NIEHS NIH HHS R01 ES023485NIH HHS S10 OD018006
6 · The paper itself

Abstract

objectiveA study was conducted using serum samples and high-resolution metabolomics (HRM) to test for changes in abundance of environmental chemicals in deployment in high-risk areas (Balad, Iraq; Bagram, Afghanistan).

methodsPre and Post-deployment serum samples for deployment (cases) and matched controls stationed domestically were analyzed by HRM and bioinformatics for the relative abundance of 271 environmental chemicals.

resultsOf the 271 chemicals, 153 were measurable in at least 80% of the samples in one of the pre- or post-deployment groups. Several pesticides and other chemicals were modestly elevated post-deployment in the Control as well as the Bagram and Balad samples. Similarly, small decreases were seen for some chemicals.

conclusionThese results using serum samples show that for the 271 environmental chemicals studied, 56% were detected and small differences occurred with deployment to high-risk areas.

Indexed as

Afghan Campaign 2001-Environmental ExposureEnvironmental PollutantsHumansMass SpectrometryMetabolomicsMilitary PersonnelRisk FactorsUnited StatesEnvironmental Pollutants

Identifiers

PMID31800447
PMCPMC7299071

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.