Evidence map›Paper›PMID 31800404›Full record

ArticleAIDS (London, England)2019

Parameter estimates for trends and patterns of excess mortality among persons on antiretroviral therapy in high-income European settings.

Adam Trickey, Ard van Sighem, John Stover, Sophie Abgrall, Sophie Grabar, Fabrice Bonnet, Juan Berenguer, Christoph Wyen, Jordi Casabona, Antonella d'Arminio Monforte and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Adam TrickeyaPopulation Health Sciences, University of Bristol, Bristol, UK bStichting HIV Monitoring, Amsterdam, The Netherlands cAvenir Health, Glastonbury, Connecticut, USA dDepartment of Internal Medicine, Antoine Béclère Hospital, Clamart eUniversity of Paris Saclay, Paris-Sud University, UVSQ fCESP INSERM U1018, Le Kremlin-Bicêtre gSorbonne Université, INSERM, Institut Pierre Louis d'épidemiologie et de Santé Publique (IPLESP), Unité de Biostatistique et d'épidémiologie Groupe hospitalier Cochin Broca Hôtel-Dieu, Assistance Publique Hôpitaux de Paris (AP-HP), and Université Paris Descartes, Sorbonne Paris Cité, Paris hUniversity of Bordeaux, ISPED, INSERM U1219 and CHU de Bordeaux, Bordeaux, France iHospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain jFirst Department of Internal Medicine, University of Cologne, Cologne, Germany kCEEISCAT/Agència de Salut Pública de Catalunya, Campus Can Ruti and CIBERESP, Badalona, Catalonia, Spain lClinic of Infectious and Tropical Diseases, Department of Health Sciences, ASST Santi Paolo e Carlo, University of Milan, Milan, Italy mService of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland nNational Epidemiology Center, Carlos III Health Institute, Madrid, Spain and National Plan on AIDS, Ministry of Health, Madrid, Spain oInnsbruck Medical University, Austria pDivision of Infectious Diseases, University of Calgary, Calgary, Canada qDepartment of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark.
Ard van Sighem
John Stover
Sophie Abgrall
Sophie Grabar
Fabrice Bonnet
Juan Berenguer
Christoph Wyen
Jordi Casabona
Antonella d'Arminio Monforte
Matthias Cavassini
Julia Del Amo
Robert Zangerle
M John Gill
Niels Obel
Jonathan A C Sterne
Margaret T May

Funding

1/3 Collaborative Research in HIV/AIDS, Alcohol, and Related Comorbidities (COMpAAAS) Tripartite: ART-CC, KP, and VAU01AA026209 · NIAAA · UNIVERSITY OF BRISTOL · PI STERNE, JONATHAN · 2017 to 2021
$2.2M
Medical Research Council G0100221Medical Research Council G0700820Medical Research Council MR/J002380/1NIAAA NIH HHS U01 AA026209
6 · The paper itself

Abstract

introductionHIV cohort data from high-income European countries were compared with the UNAIDS Spectrum modelling parameters for these same countries to validate mortality rates and excess mortality estimates for people living with HIV (PLHIV) on antiretroviral therapy (ART).

methodsData from 2000 to 2015 were analysed from the Antiretroviral Therapy Cohort Collaboration (ART-CC) for Austria, Denmark, France, Italy, the Netherlands, Spain, and Switzerland. Flexible parametric models were used to compare all-cause mortality rates in the ART-CC and Spectrum. The percentage of AIDS-related deaths and excess mortality (both are the same within Spectrum) were compared, with excess mortality defined as that in excess of the general population mortality.

resultsAnalyses included 94 026 PLHIV with 585 784 person-years of follow-up, from which there were 5515 deaths. All-cause annual mortality rates in Spectrum for 2000-2003 were 0.0121, reducing to 0.0078 in 2012-2015, whilst the ART-CC's corresponding annual mortality rates were 0.0151 [95% confidence interval (95% CI): 0.0130-0.0171] reducing to 0.0049 (95% CI: 0.0039-0.0060). The percentage of AIDS-related deaths in Spectrum was 74.7% in 2000-2003, dropping to 43.6% in 2012-2015. In the ART-CC, AIDS-related mortality constitutes 45.3% (95% CI: 38.4-52.9%) of mortality in 2000-2003 and 26.7% (95% CI: 19-46%) between 2012 and 2015. Excess mortality in the ART-CC was broadly similar to the Spectrum estimates, dropping from 75.3% (95% CI: 60.3-95.2%) in 2000-2003 to 30.7% (95% CI: 25.5-63.7%) in 2012-2015.

conclusionAll-cause mortality assumptions for PLHIV on ART in high-income European settings should be adjusted in Spectrum to be higher in 2000-2003 and decline more quickly to levels currently captured for recent years.

Indexed as

Developed CountriesAdultAnti-HIV AgentsCohort StudiesEuropeFemaleHIV InfectionsHumansMaleMiddle AgedModels, StatisticalMortalityRisk FactorsAnti-HIV Agents

Identifiers

PMID31800404
PMCPMC6919232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.