Evidence map›Paper›PMID 31800264›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2020

Inhibition of ATP hydrolysis restores airway surface liquid production in cystic fibrosis airway epithelia.

Catharina van Heusden, Brian Button, Wayne H Anderson, Agathe Ceppe, Lisa C Morton, Wanda K O'Neal, Hong Dang, Neil E Alexis, Scott Donaldson, Holger Stephan and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Mucus plugs-associated gene expression identifies pathophysiology shared with chronic bronchitis.American journal of respiratory and critical care medicine · 2026
    Article
  3. PMInternational journal of medical sciences · 2024
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Hyperinflammation and airway surface liquid dehydration in cystic fibrosis: purinergic system as therapeutic target.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021
    Review
  9. Review
  10. Purinergic receptors in airway hydration.Biochemical pharmacology · 2021
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Catharina van HeusdenMarsico Lung Institute/UNC CF Research Center, University of North Carolina, Chapel Hill, North Carolina.
Brian ButtonMarsico Lung Institute/UNC CF Research Center, University of North Carolina, Chapel Hill, North Carolina.
Wayne H AndersonMarsico Lung Institute/Pulmonary and Critical Care Medicine, University of North Carolina, Chapel Hill, North Carolina.
Agathe CeppeMarsico Lung Institute/UNC CF Research Center, University of North Carolina, Chapel Hill, North Carolina.
Lisa C MortonMarsico Lung Institute/UNC CF Research Center, University of North Carolina, Chapel Hill, North Carolina.
Wanda K O'NealMarsico Lung Institute/UNC CF Research Center, University of North Carolina, Chapel Hill, North Carolina.
Hong DangMarsico Lung Institute/UNC CF Research Center, University of North Carolina, Chapel Hill, North Carolina.
Neil E AlexisCenter for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, North Carolina.
Scott DonaldsonMarsico Lung Institute/UNC CF Research Center, University of North Carolina, Chapel Hill, North Carolina.
Holger StephanHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany.
Richard C BoucherMarsico Lung Institute/UNC CF Research Center, University of North Carolina, Chapel Hill, North Carolina.
Eduardo R LazarowskiMarsico Lung Institute/UNC CF Research Center, University of North Carolina, Chapel Hill, North Carolina.
Lung Institute · USHelmholtz-Zentrum Dresden-Rossendorf · DE

Funding

Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Martina Gentzsch · 2004 to 2026
$26.5M
The Biophysics of Mucus Hydration and Adhesion/CohesionP01HL108808 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUBINSTEIN, MICHAEL · 2012 to 2021
$23.9M
The Mucus Transport Apparatus: Why Two Layers?P50HL084934 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES · 2006 to 2010
$15.6M
Purinergic Control of CFTR-ENaC Interactions in Alveolar EpitheliaP01HL110873 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES · 2012 to 2016
$10.7M
Synthesis of Effective and Safe Mucolytics for Pulmonary DiseaseUH3HL123645 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES · 2016 to 2018
$4.6M
Multiscale Biochemical/Biophysical Integration of Pulmonary Mucus TransportR01HL136961 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES · 2017 to 2020
$3.2M
The role of mucus and pulmonary surface interactions in lung defenseR01HL125280 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUTTON, BRIAN M · 2015 to 2023
$3.1M
Regulation of airway mucus hydration/clearance by released nucleotidesR56HL136909 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAZAROWSKI, EDUARDO RODOLFO · 2018 to 2018
$532k
NHLBI NIH HHS P01 HL108808NHLBI NIH HHS P01 HL110873NHLBI NIH HHS P50 HL084934NHLBI NIH HHS R01 HL125280NHLBI NIH HHS R01 HL136961NHLBI NIH HHS R56 HL136909NHLBI NIH HHS UH3 HL123645NIDDK NIH HHS P30 DK065988
6 · The paper itself

Abstract

Airway surface dehydration is a pathological feature of cystic fibrosis (CF) lung disease. CF is caused by mutations in the CF transmembrane conductance regulator (CFTR), a cyclic AMP-regulated Cl

Indexed as

Adenosine TriphosphatasesAdenosine TriphosphateAlkaline PhosphataseBronchiCystic FibrosisEnzyme InhibitorsEpithelial CellsHumansHydrolysisPolyoxometalatesRespiratory MucosaSputumTungsten CompoundsAdenosine TriphosphatasesAdenosine TriphosphateAlkaline PhosphataseectoATPaseEnzyme Inhibitorspolyoxometalate IPolyoxometalatesTungsten Compoundscystic fibrosisecto-ATPasesextracellular ATPpolyoxometalatespurinergic receptors

Identifiers

PMID31800264
PMCPMC7052677
OpenAlexW2992776058

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.