Evidence map›Paper›PMID 31800262›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2020

SPECT imaging of lung ischemia-reperfusion injury using [

Eric J Charles, Mahendra D Chordia, Yunge Zhao, Yi Zhang, J Hunter Mehaffey, David K Glover, Julien Dimastromatteo, W Zachary Chancellor, Ashish K Sharma, Irving L Kron and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Retention ofACS infectious diseases · 2021
    Article
  7. Sterile inflammation in thoracic transplantation.Cellular and molecular life sciences : CMLS · 2021
    Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Eric J CharlesDepartment of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia.
Mahendra D ChordiaDepartment of Radiology and Medical Imaging, University of Virginia School of Medicine, Charlottesville, Virginia.
Yunge ZhaoDepartment of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia.
Yi ZhangBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.
J Hunter MehaffeyDepartment of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia.
David K GloverDepartment of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia.
Julien DimastromatteoDepartment of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, Virginia.
W Zachary ChancellorDepartment of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia.
Ashish K SharmaDepartment of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia.
Irving L KronDepartment of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia.
Dongfeng PanDepartment of Radiology and Medical Imaging, University of Virginia School of Medicine, Charlottesville, Virginia.
Victor E LaubachDepartment of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia.ORCID 0000-0001-9673-5383
University of Virginia · USCedars-Sinai Medical Center · US

Funding

Cardiovascular Surgery Training ProgramT32HL007849 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI KRON, IRVING L., LAUBACH, VICTOR E · 1998 to 2025
$7.0M
Network for Cardiothoracic Surgical Investigations in Cardiovascular MedicineUM1HL088925 · NHLBI · UNIVERSITY OF VIRGINIA · PI BADHWAR, VINAY, KRON, IRVING L. · 2013 to 2025
$6.8M
Adenosine A2 Receptors and Imaging of Inflammation in Lung Reperfusion InjuryR01HL130053 · NHLBI · UNIVERSITY OF VIRGINIA · PI KRON, IRVING L., LAUBACH, VICTOR E · 2017 to 2020
$2.6M
NHLBI NIH HHS R01 HL130053NHLBI NIH HHS T32 HL007849NHLBI NIH HHS UM1 HL088925
6 · The paper itself

Abstract

Primary graft dysfunction after lung transplantation, a consequence of ischemia-reperfusion injury (IRI), is a major cause of morbidity and mortality. IRI involves acute inflammation and innate immune cell activation, leading to rapid infiltration of neutrophils. Formyl peptide receptor 1 (FPR1) expressed by phagocytic leukocytes plays an important role in neutrophil function. The cell surface expression of FPR1 is rapidly and robustly upregulated on neutrophils in response to inflammatory stimuli. Thus, we hypothesized that use of [

Indexed as

Tomography, Emission-Computed, Single-PhotonAnimalsLungMice, Inbred C57BLNeutrophil InfiltrationOligopeptidesOptical ImagingReceptors, Formyl PeptideReperfusion InjuryTissue Distributioncinnamoyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanineOligopeptidesReceptors, Formyl Peptideformyl peptide receptorischemia-reperfusion injurylung transplantmolecular imagingSPECT

Identifiers

PMID31800262
PMCPMC7052676
OpenAlexW2993125611

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.