Evidence map›Paper›PMID 31799904›Full record

ReviewPhysiology (Bethesda, Md.)2020

Nonlinear Input-Output Functions of Motoneurons.

Marc D Binder, Randall K Powers, C J Heckman

Abstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. 5-HTThe Journal of physiology · 2025
    Trial
  3. Article
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  6. Article
  7. Article
  8. Review
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  11. Motor unit mechanisms of speed control in mouse locomotion.bioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. A novel protocol to investigate the monoaminergic relationship between descending nociceptive and motor unit neuromodulation.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Marc D BinderDepartment of Physiology & Biophysics, University of Washington School of Medicine, Seattle, Washington.
Randall K PowersDepartment of Physiology & Biophysics, University of Washington School of Medicine, Seattle, Washington.
C J HeckmanDepartments of Physiology, Physical Medicine & Rehabilitation, Physical Therapy & Human Movement Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Funding

Motoneuron mortality in neurodegenerative diseases induced by homeostatic dysregulation of excitabilityR01NS110953 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BINDER, MARC D, HECKMAN, CHARLES · 2019 to 2023
$2.8M
The Human Motor Output MapR01NS098509 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HECKMAN, CHARLES · 2016 to 2020
$2.1M
Mechanisms of Distorted Inputs in Chronic Spinal InjuryR01NS089313 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HECKMAN, CHARLES · 2014 to 2018
$1.7M
NINDS NIH HHS R01 NS089313NINDS NIH HHS R01 NS098509NINDS NIH HHS R01 NS110953
6 · The paper itself

Abstract

All movements are generated by the activation of motoneurons, and hence their input-output properties define the final step in processing of all motor commands. A major challenge to understanding this transformation has been the striking nonlinear behavior of motoneurons conferred by the activation of persistent inward currents (PICs) mediated by their voltage-gated Na

Indexed as

AnimalsHumansMembrane PotentialsMotor NeuronsNerve NetSodiumSpinal CordSodiuminput-output functionmotoneuronnonlinear behaviorpersistent inward currents

Identifiers

PMID31799904
PMCPMC7132324

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.