Evidence map›Paper›PMID 31799808›Full record

ArticleObesity (Silver Spring, Md.)2020

It's Absolutely Relative: The Effect of Age on the BMI-Mortality Relationship in Postmenopausal Women.

Hailey R Banack, Jennifer W Bea, Andrew Stokes, Candyce H Kroenke, Marcia L Stefanick, Shirley A Beresford, Chloe E Bird, Lorena Garcia, Robert Wallace, Robert A Wild and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Associations Between Mid- to Late-Life Body Mass Index and Chronic Disease-Free Survival: A Nationwide Twin Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hailey R BanackDepartment of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, New York, USA.ORCID 0000-0002-6230-2245
Jennifer W BeaDepartment of Nutrition Sciences, University of Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA.
Andrew StokesDepartment of Global Health and Center for Global Health and Development, Boston University School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-8502-3636
Candyce H KroenkeDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Marcia L StefanickDivision of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
Shirley A BeresfordDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.
Chloe E BirdRAND Corporation, Santa Monica, California, USA.
Lorena GarciaDepartment of Public Health Sciences, University of California, Davis, Davis, California, USA.
Robert WallaceDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA.
Robert A WildDepartment of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Bette CaanDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Jean Wactawski-WendeDepartment of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, New York, USA.

Funding

VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVEN01WH032122 · WH · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI TREVISAN, MAURIZIO · 1993 to 2000
$927k
CIHRNHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CWHI NIH HHS N01 WH032122
6 · The paper itself

Abstract

objectiveThe use of relative and absolute effect estimates has important implications for the interpretation of study findings. Likewise, examining additive and multiplicative interaction can lead to differing conclusions about the joint effects of two exposure variables. The aim of this paper is to examine the relationship between BMI and mortality on the relative and absolute scales and investigate interaction between BMI and age.

methodsData from 68,132 participants in the Women's Health Initiative (WHI) study were used. The risk ratio and risk difference of BMI on mortality were estimated. A product term was also included to examine interaction between BMI and age on the multiplicative scale, and the relative excess risk of interaction was calculated to measure additive interaction.

resultsResults demonstrated that the mortality risk ratio decreased as women aged, but the mortality risk difference increased as women aged. Evidence of additive and multiplicative interaction between age and BMI was found.

conclusionsIn postmenopausal women, the relative mortality risk associated with high BMI decreased with increasing age, but the absolute risk of high BMI increased with increasing age. This indicates the importance of considering the interaction between age and BMI to understand mortality risk in older women.

Indexed as

Body Mass IndexAgedAge FactorsFemaleHumansMortalityObesityPostmenopauseRisk FactorsTreatment OutcomeWomen's Health

Identifiers

PMID31799808
PMCPMC6989046

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.