GRÖMeR: A Pipeline for Geodesic Refinement of Mesh Registration.

The electrical signals produced by the heart can be used to assess cardiac health and diagnose adverse pathologies. Experiments on large mammals provide essential sources of these signals through measurements of up to 1000 simultaneous, distributed locations throughout the heart and torso. To perform accurate spatial analysis of the resulting electrical recordings, researchers must register the locations of each electrode, typically by defining correspondence points from post-experiment, three-dimensional imaging, and directly measured surface electrodes. Often, due to the practical limitations of the experimental situation, only a subset of the electrode locations can be measured, from which the rest must be estimated. We have developed a pipeline, GRÖMeR, that can perform registration of cardiac surface electrode arrays given a limited correspondence point set. This pipeline accounts for global deformations and uses a modified iterative closest points algorithm followed by a geodesically constrained radial basis deformation to calculate a smooth, correspondence-driven registration. To assess the performance of this pipeline, we generated a series of target geometries and limited correspondence patterns based on experimental scenarios. We found that the best performing correspondence pattern required only 20, approximately uniformly distributed points over the epicardial surface of the heart. This study demonstrated the GRÖMeR pipeline to be an accurate and effective way to register cardiac sock electrode arrays from limited correspondence points.