Evidence map›Paper›PMID 31799489›Full record

ArticleCurrent opinion in physiology2019

Feedback regulation of locomotion by motoneurons in the vertebrate spinal cord.

Melanie Falgairolle, Michael J O'Donovan

Abstract read
In one paragraph

Article in Current opinion in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Cholinergic Modulation of Locomotor Circuits in Vertebrates.International journal of molecular sciences · 2022
    Review
  7. Recruitment of Motoneurons.Advances in neurobiology · 2022
    Article
  8. Article
  9. Article
  10. Motoneuronal Spinal Circuits in Degenerative Motoneuron Disease.Frontiers in molecular neuroscience · 2020
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Melanie FalgairolleSection on Developmental Neurobiology, NINDS, NIH, Bethesda MD 20892, USA.
Michael J O'DonovanSection on Developmental Neurobiology, NINDS, NIH, Bethesda MD 20892, USA.

Funding

NETWORK FUNCTION IN THE DEVELOPING SPINAL CORD OF THE CHICK EMBRYOZ01NS002787 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI O'DONOVAN, MICHAEL J · 1990 to 2008
$2.2M
Mechanisms of Rhythmicity in the Spinal cordZ01NS003022 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI O'DONOVAN, MICHAEL · 2007 to 2008
$2.2M
Intramural NIH HHS Z01 NS002787Intramural NIH HHS Z01 NS003022
6 · The paper itself

Abstract

Motoneurons are known to be an essential component of central pattern generators in invertebrates, but it is only recently that they have been shown to play a similar role in vertebrate locomotor circuits. Here, we review early experiments implicating motoneurons in the genesis of spontaneous motor activity in development and more recent experiments identifying motoneurons as important regulators of locomotor activity in the adult zebrafish and in the neonatal mouse spinal cord. We discuss the mechanisms responsible for these actions, the experimental challenges in studying the role of motoneurons in the mammalian spinal cord and the functional significance of the excitatory influence of motoneuron activity on locomotor behavior.

Identifiers

PMID31799489
PMCPMC6888840

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.