Evidence map›Paper›PMID 31799427›Full record

ArticleCommunications biology2019

Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a

Yuzuru Imai, Tsuyoshi Inoshita, Hongrui Meng, Kahori Shiba-Fukushima, Kiyotaka Y Hara, Naoya Sawamura, Nobutaka Hattori

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
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  8. Article
  9. Application of Optogenetics in Neurodegenerative Diseases.Cellular and molecular neurobiology · 2024
    Review
  10. Nonlethal deleterious mutation-induced stress accelerates bacterial aging.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
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  18. Article
  19. International journal of molecular sciences · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yuzuru Imai1Department of Research for Parkinson's Disease, Juntendo University Graduate School of Medicine, Tokyo, 113-8421 Japan.ORCID 0000-0003-2924-5231
Tsuyoshi Inoshita3Department of Treatment and Research in Multiple Sclerosis and Neuro-intractable Disease, Juntendo University Graduate School of Medicine, Tokyo, 113-8421 Japan.
Hongrui Meng4Department of Neurodegenerative and Demented Disorders, Juntendo University Graduate School of Medicine, Tokyo, 113-8421 Japan.
Kahori Shiba-Fukushima3Department of Treatment and Research in Multiple Sclerosis and Neuro-intractable Disease, Juntendo University Graduate School of Medicine, Tokyo, 113-8421 Japan.
Kiyotaka Y Hara5Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, 422-8526 Japan.
Naoya Sawamura6Research Organization for Nano & Life Innovation, Waseda University, Tokyo, 162-8480 Japan.ORCID 0000-0003-4753-1119
Nobutaka Hattori1Department of Research for Parkinson's Disease, Juntendo University Graduate School of Medicine, Tokyo, 113-8421 Japan.
Juntendo University · JPUniversity of Shizuoka · JPWaseda University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial degeneration is considered one of the major causes of Parkinson's disease (PD). Improved mitochondrial functions are expected to be a promising therapeutic strategy for PD. In this study, we introduced a light-driven proton transporter, Delta-rhodopsin (dR), to

Indexed as

LightMotor ActivityProtonsalpha-SynucleinAnimalsBiomarkersDisease Models, AnimalDisease SusceptibilityDopaminergic NeuronsDrosophilaMitochondriaMitochondrial DiseasesModels, BiologicalOxidative StressParkinson DiseaseReactive Oxygen Speciesalpha-SynucleinBiomarkersProtonsReactive Oxygen SpeciesCell death in the nervous systemEnergy metabolismGene expressionOptogeneticsParkinson's disease

Identifiers

PMID31799427
PMCPMC6874642
OpenAlexW2989695617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.