Evidence map›Paper›PMID 31799389›Full record

ArticleScience advances2019

Endoplasmic reticulum mediates mitochondrial transfer within the osteocyte dendritic network.

Junjie Gao, An Qin, Delin Liu, Rui Ruan, Qiyang Wang, Jun Yuan, Tak Sum Cheng, Aleksandra Filipovska, J M Papadimitriou, Kerong Dai and 6 more

Abstract read
In one paragraph

Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  4. Article
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  6. Review
  7. Article
  8. Article
  9. Article
  10. Development-based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  11. Review
  12. Review
  13. Mitochondria transfer in tissue homeostasis and diseases.International journal of biological sciences · 2026
    Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
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  20. Review

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Junjie GaoPerron Institute for Neurological and Translational Science, Nedlands, Western Australia 6009, Australia.ORCID 0000-0003-4820-8524
An QinShanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Delin LiuPerron Institute for Neurological and Translational Science, Nedlands, Western Australia 6009, Australia.
Rui RuanCentre for Orthopaedic Translational Research, Medical School, University of Western Australia, Nedlands, Western Australia 6009, Australia.ORCID 0000-0003-4947-3071
Qiyang WangDepartment of Orthopaedics, Shanghai Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China.ORCID 0000-0002-3054-4207
Jun YuanPerron Institute for Neurological and Translational Science, Nedlands, Western Australia 6009, Australia.ORCID 0000-0001-6542-4654
Tak Sum ChengCentre for Orthopaedic Translational Research, Medical School, University of Western Australia, Nedlands, Western Australia 6009, Australia.
Aleksandra FilipovskaCentre for Medical Research (affiliated with the Harry Perkins Institute of Medical Research), University of Western Australia, Nedlands, Western Australia 6009, Australia.ORCID 0000-0002-6998-8403
J M PapadimitriouCentre for Orthopaedic Translational Research, Medical School, University of Western Australia, Nedlands, Western Australia 6009, Australia.
Kerong DaiShanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Qing JiangDepartment of Sports Medicine and Adult Reconstruction Surgery, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210008, China.ORCID 0000-0002-2552-9686
Xiang GaoState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Collaborative Innovation Center of Genetics and Development, Nanjing University, Nanjing, Jiangsu 210061, China.ORCID 0000-0002-7326-2277
Jian Q FengDepartment of Biomedical Sciences, Texas A&M College of Dentistry, Dallas, TX 75246, USA.ORCID 0000-0002-3424-5909
Hiroshi TakayanagiCentre for Orthopaedic Translational Research, Medical School, University of Western Australia, Nedlands, Western Australia 6009, Australia.ORCID 0000-0002-1462-4127
Changqing ZhangDepartment of Orthopaedics, Shanghai Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China.ORCID 0000-0002-7408-4126
Ming H ZhengCentre for Orthopaedic Translational Research, Medical School, University of Western Australia, Nedlands, Western Australia 6009, Australia.ORCID 0000-0003-1185-4768

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial transfer plays a crucial role in the regulation of tissue homeostasis and resistance to cancer chemotherapy. Osteocytes have interconnecting dendritic networks and are a model to investigate its mechanism. We have demonstrated, in primary murine osteocytes with photoactivatable mitochondria (PhAM)

Indexed as

AnimalsCell LineEndoplasmic ReticulumGTP PhosphohydrolasesHomeostasisMiceMice, KnockoutMicroscopy, ConfocalMitochondriaOsteocytesGTP PhosphohydrolasesMfn2 protein, mouse

Identifiers

PMID31799389
PMCPMC6867880

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.