Evidence map›Paper›PMID 31799388›Full record

ArticleScience advances2019

Neuronal GPCR NPR-8 regulates

Durai Sellegounder, Yiyong Liu, Phillip Wibisono, Chia-Hui Chen, David Leap, Jingru Sun

Abstract read
In one paragraph

Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Article
  2. Adaptation ofmSphere · 2026
    Article
  3. Article
  4. Article
  5. Article
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  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. TheiScience · 2025
    Article
  15. Article
  16. GPCR Sense Communication Among Interaction Nematodes with Other Organisms.International journal of molecular sciences · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Durai SellegounderDepartment of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.ORCID 0000-0002-0776-0307
Yiyong LiuDepartment of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Phillip WibisonoDepartment of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Chia-Hui ChenDepartment of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.ORCID 0000-0001-7424-468X
David LeapDepartment of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Jingru SunDepartment of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.ORCID 0000-0003-1901-5600

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Neuronal and molecular mechanisms underlying neural regulation of innate immunityR35GM124678 · NIGMS · WASHINGTON STATE UNIVERSITY · PI Jingru Sun · 2017 to 2026
$4.5M
NIGMS NIH HHS R35 GM124678NIH HHS P40 OD010440
6 · The paper itself

Abstract

Increasing evidence indicates that infection-triggered host defenses are regulated by the nervous system. However, the precise mechanisms of this regulation are not well understood. Here, we demonstrate that neuronal G protein-coupled receptor NPR-8 negatively regulates

Indexed as

AnimalsAnimals, Genetically ModifiedBacterial InfectionsCaenorhabditis elegansCaenorhabditis elegans ProteinsCollagenEscherichia coliImmunity, InnateNervous SystemPseudomonas aeruginosaReceptors, G-Protein-CoupledSalmonella entericaSensory Receptor CellsSignal TransductionStaphylococcus aureusCaenorhabditis elegans ProteinsCollagenNPR-8 protein, C elegansReceptors, G-Protein-Coupled

Identifiers

PMID31799388
PMCPMC6867885

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.