ArticleJournal of molecular biochemistry2014
A series of Notch3 mutations in CADASIL; insights from 3D molecular modelling and evolutionary analyses.
Article in Journal of molecular biochemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Phenotypes Associated with NOTCH3 Cysteine-Sparing Mutations in Patients with Clinical Suspicion of CADASIL: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Systematic Review of Cysteine-Sparing NOTCH3 Missense Mutations in Patients with Clinical Suspicion of CADASIL.International journal of molecular sciences · 2017Pooled it
- Case Report: Decoding genetic risks of vascular parkinsonism: a case series.Frontiers in genetics · 2025Article
- Risk and Resilience Variants in the Retinoic Acid Metabolic and Developmental Pathways Associated with Risk of FASD Outcomes.Biomolecules · 2024Article
- Article
- Association of RareJournal of the American Heart Association · 2024Article
- Pattern of Brain Parenchymal Damage Related to Cerebral Small Vessel Disease in Carriers of RareNeurology · 2023Article
- NOTCH3 mutations in a cohort of Portuguese patients within CADASIL spectrum phenotype.Neurogenetics · 2022Article
- Article
- A novel cysteine-sparing G73A mutation of NOTCH3 in a Chinese CADASIL family.Neurogenetics · 2020Article
- NOTCH3 and CADASIL syndrome: a genetic and structural overview.EMBnet.journal · 2019Article
- Introducing Thetis: a comprehensive suite for event detection in molecular dynamics.Journal of molecular biochemistry · 2018Article
- HCV genetics and genotypes dictate future antiviral strategies.Journal of molecular biochemistry · 2017Article
- Article
- Uncovering genetic mimics in multiple sclerosis: A single-center clinical exome sequencing study.Multiple sclerosis journal - experimental, translational and clinicalArticle
- DNA Replication Inhibitor Geminin and Retinoic Acid Signaling Participate in Complex Interactions Associated With Pluripotency.Cancer genomics & proteomicsArticle
- Carcinogenic Pesticide ControlIn vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CADASIL disease belongs to the group of rare diseases. It is well established that the Notch3 protein is primarily responsible for the development of CADASIL syndrome. Herein, we attempt to shed light to the actual molecular mechanism underlying CADASIL via insights that we have from preliminary
Identifiers
31799216PMC6887539W1549593270What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.