Evidence map›Paper›PMID 31799057›Full record

ArticleBiomedical optics express2019

Brain segmentation, spatial censoring, and averaging techniques for optical functional connectivity imaging in mice.

Brian R White, Jonah A Padawer-Curry, Akiva S Cohen, Daniel J Licht, Arjun G Yodh

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Intact-skull cranial windows for widefield optical imaging in juvenile mice: complications and consequences.Journal of the Optical Society of America. A, Optics, image science, and vision · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Variability in atlas registration of optical intrinsic signal imaging and its effect on functional connectivity analysis.Journal of the Optical Society of America. A, Optics, image science, and vision · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Brian R WhiteDivision of Pediatric Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia. 3401 Civic Center Blvd., Pediatric Cardiology - 8NW, Philadelphia, PA 19104, USA.ORCID https://orcid.org/0000-0001-5196-2339
Jonah A Padawer-CurryDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia. 3501 Civic Center Blvd., Philadelphia, PA 19104, USA.
Akiva S CohenDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia. 3615 Civic Center Blvd., Abramson Research Center, Room 816-H, Philadelphia, PA 19104, USA.
Daniel J LichtDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia. 3501 Civic Center Blvd., Philadelphia, PA 19104, USA.
Arjun G YodhDepartment of Physics and Astronomy, University of Pennsylvania. 3231 Walnut St., Philadelphia, PA 19104, USA.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

Training in Molecular Therapeutics for Pediatric CardiologyT32HL007915 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Robert J Levy, JOSEPH W ROSSANO · 1999 to 2026
$13.4M
Training and DisseminationP41EB015893 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2012 to 2019
$11.3M
Diffuse Optics for Acute Stroke ManagementR01NS060653 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI YODH, ARJUN G. · 2008 to 2018
$5.5M
NHLBI NIH HHS T32 HL007915NIBIB NIH HHS P41 EB015893NINDS NIH HHS R01 NS060653
6 · The paper itself

Abstract

Resting-state functional connectivity analysis using optical neuroimaging holds the potential to be a powerful bridge between mouse models of disease and clinical neurologic monitoring. However, analysis techniques specific to optical methods are rudimentary, and algorithms from magnetic resonance imaging are not always applicable to optics. We have developed visual processing tools to increase data quality, improve brain segmentation, and average across sessions with better field-of-view. We demonstrate improved performance using resting-state optical intrinsic signal from normal mice. The proposed methods increase the amount of usable data from neuroimaging studies, improve image fidelity, and should be translatable to human optical neuroimaging systems.

Identifiers

PMID31799057
PMCPMC6865125
OpenAlexW2982612854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.