ArticleBiomaterials research2019
Comparison of cytotoxicity of black phosphorus nanosheets in different types of fibroblasts.
Article in Biomaterials research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Black Phosphorus Nanosheets Penetrate the Blood-Testis Barrier and Induce Reproductive Toxicity in Male Mice.Environment & health (Washington, D.C.) · 2026Article
- Atomic-Scale Insights into Phosphorene-Ionic Liquid Interface with Ab Initio Molecular Dynamics.ACS physical chemistry Au · 2026Article
- Nano-Enabled Fluorescence Switching: A Novel Strategy for PDGFRβ Detection and TKI Therapy Monitoring.Research (Washington, D.C.) · 2026Article
- Nanomaterials and nanotechnology in otolaryngology: a narrative review.Nanomedicine (London, England) · 2025Review
- Article
- 3D bioprintable MgTheranostics · 2025Article
- Black Phosphorus Nanoflakes: An Emerging Nanomaterial for Clinical Wound Management and Biomedical Applications.International journal of molecular sciences · 2024Review
- Protective Role of Melatonin against Liver Toxicity from Black Phosphorus Nanosheets via Oxidative Stress and Pyroptosis.ACS omega · 2024Article
- Emerging 2D Nanomaterials-Integrated Hydrogels: Advancements in Designing Theragenerative Materials for Bone Regeneration and Disease Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Influence of Polypyrrole on Phosphorus- and TiONanomaterials (Basel, Switzerland) · 2024Article
- The effect of charge and albumin on cellular uptake of supramolecular polymer nanostructures.Journal of materials chemistry. B · 2024Article
- Screening 2D Materials for Their Nanotoxicity toward Nucleic Acids and Proteins: An In Silico Outlook.ACS physical chemistry Au · 2024Review
- Covalently Bonded Ni Sites in Black Phosphorene with Electron Redistribution for Efficient Metal-Lightweighted Water Electrolysis.Nano-micro letters · 2024Article
- Black phosphorous-based human-machine communication interface.Nature communications · 2023Article
- Ternary MXene-loaded PLCL/collagen nanofibrous scaffolds that promote spontaneous osteogenic differentiation.Nano convergence · 2022Article
- Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering.Nano-micro letters · 2021Review
- In Vivo Enrichment and Elimination of Circulating Tumor Cells by Using a Black Phosphorus and Antibody Functionalized Intravenous Catheter.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTwo-dimensional black phosphorus nanosheets (BPNSs) have recently emerged as a successive novel nanomaterial owing to their uniqueness in optical and electrical properties. Although BPNSs have found a wide range of biomedical applications, their biosafety is still a major concern to be addressed.
methodsIn this study, we have prepared layered BPNSs using liquid exfoliation procedure, and evaluated their physicochemical properties using Fourier Transform-infrared (FTIR) spectroscopy, Raman spectroscopy, atomic force microscopy, and Zetasizer analyses. We have investigated potential cytotoxicity of BPNSs against three different types of fibroblast cells, i.e. mouse embryonic fibroblast (NIH3T3), primary cultured normal human dermal fibroblast (nHDF), and fibrosarcoma (HT1080). Cell counting kit-8 (CCK-8) assay was carried out to assess cellular metabolic activity in cells whereas lactate dehydrogenase (LDH) activity assay was helpful to study plasma membrane integrity.
resultsOur salient research findings showed that BPNSs were polydispersed in solution due to aggregation. Toxic response of BPNSs against fibroblast cells was in the order, HT1080>nHDF>NIH3T3. The nanosheets reduced the number of cancerous cells with significant difference to normal cells.
conclusionsWe suggest that BPNSs can be considered for cancer treatment as they destroy cancerous cells effectively. However, a comprehensive study is required to elucidate other biological effects of BPNSs.
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