ArticleBMJ open diabetes research & care2019
Retinopathy progression and the risk of end-stage kidney disease: results from a longitudinal Japanese cohort of 232 patients with type 2 diabetes and biopsy-proven diabetic kidney disease.
Article in BMJ open diabetes research & care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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37 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Acute Kidney Injury from Intravitreal Anti-vascular Endothelial Growth Factor Drugs: A Systematic Review and Meta-analysis of Randomized Controlled Trials.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2023Pooled it
- Diabetic Retinopathy Severity and Heart Failure Outcomes in Type 2 Diabetes Mellitus.Journal of diabetes · 2026Article
- Literature-informed ensemble machine learning for three-year diabetic kidney disease risk prediction in type 2 diabetes: Development, validation, and deployment of the PSMMC NephraRisk model.Diabetes, obesity & metabolism · 2026Article
- Diabetic retinopathy Is associated with histologic severity of diabetic kidney disease and systemic inflammation.Acta diabetologica · 2026Article
- Clinical Model Predicting Presence of Diabetic Nephropathy in Renal Biopsy Performed on Patients with Diabetes.Journal of clinical medicine · 2026Article
- Development and validation of an explainable machine learning model for differentiating diabetic nephropathy from diabetic retinopathy in patients with type 2 diabetes.Frontiers in endocrinology · 2026Article
- Lower hemoglobin levels may increase the risk of diabetic retinopathy in patients with type 2 diabetes mellitus.BMC endocrine disorders · 2025Article
- Prediction of advanced chronic kidney disease through retinal fundus images by deep learning.Scientific reports · 2025Article
- Diabetic retinopathy and diabetic kidney disease, either isolated or associated, impact on the 10-year risk of cardiovascular disease: are we dealing with similar conditions?Archives of endocrinology and metabolism · 2025Article
- Association between blood urea nitrogen to albumin ratio and diabetic retinopathy: insights from the US National Health and Nutrition Examination Survey.International journal of ophthalmology · 2025Article
- Kidney Biopsy Findings Among Patients With Diabetes in the Cleveland Clinic Kidney Biopsy Epidemiology Project.Kidney medicine · 2024Article
- Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes.Cardiovascular diabetology · 2024Article
- Correlation of glucose and lipid metabolism, renal function and retinopathy in diabetic retinopathy patients using OCTA detection.American journal of translational research · 2024Article
- Risk evaluation for diabetic retinopathy in Chinese renal-biopsied type 2 diabetes mellitus patients.International journal of ophthalmology · 2024Article
- The coexistence of diabetic retinopathy and diabetic nephropathy is associated with worse kidney outcomes.Clinical kidney journal · 2023Article
- A closer association between blood urea nitrogen and the probability of diabetic retinopathy in patients with shorter type 2 diabetes duration.Scientific reports · 2023Article
- Diabetic vascular diseases: molecular mechanisms and therapeutic strategies.Signal transduction and targeted therapy · 2023Review
- Simultaneous attenuation of hyperglycemic memory-induced retinal, pulmonary, and glomerular dysfunctions by proinsulin C-peptide in diabetes.BMC medicine · 2023Article
- Correlation between diabetic retinopathy and diabetic nephropathy: a two-sample Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Renal impairment may indicate postoperative low vision in young patients with proliferative diabetic retinopathy undergoing vitrectomy.Frontiers in endocrinology · 2023Article
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Authors and funding
9 authors at 4 institutions in 1 country.
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Abstract
Objective: The predictive value of diabetic retinopathy on end-stage kidney disease (ESKD) has not been fully addressed in patients with type 2 diabetes and diabetic kidney disease. Research design and methods: We studied 232 patients with type 2 diabetes and biopsy-proven diabetic kidney disease who were screened for diabetic retinopathy during the 1 month of kidney biopsy. We examined the association between retinopathy progression and renal lesions. We used Cox regression analyses to explore the risk of ESKD adjusting for known risk demographic and clinical variables. We assessed the incremental prognostic value of ESKD by adding diabetic retinopathy to the clinical variables. Results: The diabetic retinopathy progression positively correlated with all scores of renal lesions, especially with the glomerular-based classification (r=0.41), scores of interstitial fibrosis (r=0.41) and diffuse lesion (r=0.48). During a median follow-up of 5.7 years, 114 patients developed ESKD. Adjusting for known risk factors of ESKD, the HR for ESKD (patients with no apparent retinopathy as a reference) were 1.96 (95% CI 0.62 to 6.17) for patients with mild non-proliferative diabetic retinopathy (NPDR), 3.10 (95% CI 1.45 to 6.65) for patients with moderate NPDR, 3.03 (95% CI 1.44 to 6.37) for patients with severe NPDR, and 3.43 (95% CI 1.68 to 7.03) for patients with proliferative diabetic retinopathy, respectively. Addition of the retinopathy grading to the clinical model alone improved the prognostic value (the global χ Conclusions: Retinopathy progression appeared to be associated with renal lesions and the development of ESKD. Our findings suggest that diabetic retinopathy and kidney disease share the same magnitude of disease progression, and therefore diabetic retinopathy may be useful for prognosticating the clinical course for diabetic kidney disease.
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