ArticleEuropean journal of hospital pharmacy : science and practice2019
Metronidazole- and levofloxacin-induced psychotic disorders in chronic kidney patient.
Article in European journal of hospital pharmacy : science and practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 7 citations in OpenAlex.
- Metronidazole-associated mood changes: A case report.Exploratory research in clinical and social pharmacy · 2026Article
- Depressive and Other Adverse CNS Effects of Fluoroquinolones.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Management of a rare case of metronidazole-induced encephalopathy presenting as posterior reversible encephalopathy syndrome: a case report.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Delirium Associations with Antibiotics: A Pharmacovigilance Study of the FDA Adverse Event Reporting System (FAERS).Drugs - real world outcomes · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
We present a case which reports the occurrence of psychotic disorders after metronidazole and levofloxacin therapy in a chronic kidney patient while being treated for enterocolitis and urinary infection. A 48-year-old female was admitted to a hospital for the placement of a peritoneal dialysis catheter due to indicated peritoneal dialysis. During admission, symptoms of enterocolitis and urinary infection had occurred, so metronidazole and levofloxacin were introduced into therapy, respectively. After 4 days of metronidazole and 3 days of levofloxacin therapy, the patient became confused, disoriented, with signs of delirium. Since the diagnosis of psychoorganic disorder was made, the therapy with lorazepam and haloperidol was initiated, while metronidazole and levofloxacin were discontinued. Complete recovery 4 days after discontinuation indicates that the patient has experienced antibiotics-induced neurotoxicity. This is the first report of expressed neurotoxicity after the combination of metronidazole and levofloxacin in chronic kidney patients.
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