ArticleMalawi medical journal : the journal of Medical Association of Malawi2018
Health-Related Quality of Life (HRQoL) scores vary with treatment and may identify potential defaulters during treatment of tuberculosis.
Article in Malawi medical journal : the journal of Medical Association of Malawi, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 20 citations in OpenAlex.
- Cost-effectiveness of BPaL/BPaLM as compared to mixed standard of care bedaquiline containing regimen for MDR/RR-TB.The Indian journal of medical research · 2025Article
- Impaired Lung Function and Quality of Life Outcomes in Patients with Tuberculosis: A Cross-Sectional Study.Tropical medicine and infectious disease · 2025Article
- Article
- Comparing cost-effectiveness of short-course regimens for drug-resistant tuberculosis treatment in India.International journal of technology assessment in health care · 2025Article
- The effects of stigma and social support on the health-related quality of life of people with drug resistance tuberculosis in Lagos, Nigeria.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Health related quality of life of tuberculosis patients in South India: A longitudinal assessment study.PloS one · 2025Article
- Quality of life among drug-resistant tuberculosis patients on treatment in SouthWest Nigeria.African health sciences · 2024Article
- The Cost-Effectiveness of the BEAT-TB Regimen for Pre-Extensively Drug-Resistant TB.Tropical medicine and infectious disease · 2023Article
- Cost Effectiveness of a Shorter Moxifloxacin Based Regimen for Treating Drug Sensitive Tuberculosis in India.Tropical medicine and infectious disease · 2022Article
- Health-Related Quality of Life (HRQoL) of Patients with Tuberculosis: A Review.Infectious disease reports · 2022Review
- Prospective Evaluation of Positivity Rates ofFrontiers in cellular and infection microbiology · 2022Article
- Correlates of quality of life among persons living with tuberculosis: A cross-sectional study.PloS one · 2022Article
- Determinants of health-related quality of life in drug-susceptible tuberculosis patients in Ghana: a prospective observational study.Therapeutic advances in infectious diseaseArticle
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7 authors at 1 institution in 1 country.
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Abstract
introductionNigeria ranks third among the 22 high-burden TB countries in the world. With the availability of effective treatment strategies, and more patients surviving the disease, assessment of Patient Reported Outcomes (PROs) has become imperative to assist with patient evaluation of measured outcomes and thus improve morbidity. Literature is scarce on assessment and impact of chemotherapy on Health-Related Quality of Life (HRQoL) for patients with tuberculosis.
aimThis study evaluates the variation in Health-Related Quality of Life (HRQoL) in pulmonary TB patients during the intensive phase of treatment.
methodsWe recruited patients with pulmonary TB (PTB), from 3 different TB clinics across Ife Ijesha Zone, Osun State, Nigeria. Consenting patients were administered Short Form-36 HRQoL questionnaire at recruitment and at the end of intensive phase of treatment. HRQoL scores were compared at these two-time points, the degrees of changes were calculated and relationships with some. Directly Observed Therapy-Short (DOTS) course outcome measures were obtained. Logistic regression was used to identify factors associated with greatest change in HRQoL scores.
resultsOf the 130 recruited patients, we analysed data for 126 patients who met the inclusion criteria. Mean age was 36.7(SD15.5). The overall mean HRQoL score obtained at enrolment was 43.18 (SD 17.2) and 60.22 (SD19.83) at end of 2 months; mean change =17.04 p<0.001). The least change was on the emotional well-being domain (mean change = 4.24, p=0.05). Predictor of significant change in HRQoL scores were previous history of TB, HIV status and TB severity, p<0.05 each. High physical functioning score was a strong predictor of defaulters (OR = 5.3; 95%CI: 2.11-9.05, p = 0.01).
conclusionEmotional domain is least affected by PTB while younger patients with no physical impairment are more likely to default treatment. Various aspects of HRQoL can be a useful tool for patient's evaluation and outcome prediction.
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