Evidence map›Paper›PMID 31798767›Full record

ArticleGenes & cancer2019

Genomic alterations of Tenascin C in highly aggressive prostate cancer: a meta-analysis.

Prachi Mishra, Michael A Kiebish, Jennifer Cullen, Alagarsamy Srinivasan, Aliyah Patterson, Rangaprasad Sarangarajan, Niven R Narain, Albert Dobi

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Prachi MishraHenry Jackson Foundation for Advancement of Military Medicine, Bethesda, MD, USA.
Michael A KiebishBERG LLC., Framingham, MA, USA.
Jennifer CullenHenry Jackson Foundation for Advancement of Military Medicine, Bethesda, MD, USA.
Alagarsamy SrinivasanCenter for Prostate Disease Research, USU-Walter Reed Surgery, Bethesda, MD, USA.
Aliyah PattersonDivision of Science and Mathematics, University of the District of Columbia, Washington DC, USA.
Rangaprasad SarangarajanBERG LLC., Framingham, MA, USA.
Niven R NarainBERG LLC., Framingham, MA, USA.
Albert DobiHenry Jackson Foundation for Advancement of Military Medicine, Bethesda, MD, USA.
Henry M. Jackson Foundation · USWalter Reed Army Institute of Research · USUniversity of the District of Columbia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tenascin C (TNC), an extra-cellular matrix (ECM) family gene, is expressed in several cancer tissues of breast, lung, colon, and gastrointestinal tract leading to proliferation, migration, invasion, angiogenesis and metastasis, but its role in tumorigenesis of prostate cancer is poorly understood. We took a meta-analysis approach to characterize the alterations of TNC gene in prostate cancer using publicly available databases (cBioportal Version 2.2.0, http://www.cBioportal.org/index.do). The analysis identified TNC alterations (gene amplification) significantly in the neuroendocrine prostate cancer dataset (Trento/Broad/Cornell,

Indexed as

biomarkersneuroendocrine subtypeprostate cancerTCGATenascin C

Identifiers

PMID31798767
PMCPMC6872669
OpenAlexW2997579901

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.