Evidence map›Paper›PMID 31798754›Full record

ArticleGenes & nutrition2019

Increased protein intake affects pro-opiomelanocortin (POMC) processing, immune function and IGF signaling in peripheral blood mononuclear cells of home-dwelling old subjects using a genome-wide gene expression approach.

Gyrd O Gjevestad, Kirsten B Holven, Amanda Rundblad, Arnar Flatberg, Mari Myhrstad, Karina Karlsen, Shivaprakash J Mutt, Karl-Heinz Herzig, Inger Ottestad, Stine M Ulven

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02218333 (Effect of Milk Proteins on Body Composition, Muscle Strength, Inflammation and Bone Health in Elderly Subjects), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02218333 nacompletednot on this map

Effect of Milk Proteins on Body Composition, Muscle Strength, Inflammation and Bone Health in Elderly Subjects

TypeinterventionalSponsorUniversity of OsloRan2014 to 2015Enrolled50ConditionsHealthyArmsMilk, Placebo
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Gyrd O Gjevestad1Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046, Blindern, 0317 Oslo, Norway.
Kirsten B Holven1Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046, Blindern, 0317 Oslo, Norway.
Amanda Rundblad1Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046, Blindern, 0317 Oslo, Norway.
Arnar Flatberg4Department of Clinical and Molecular Medicine, Faculty of Medicine, Genomics Core Facility, Norwegian University of Sciences and Technology, Olav Kyrres gt. 9, 7489 Trondheim, Norway.
Mari Myhrstad5Faculty of Health Sciences, Department of Nursing and Health Promotion, OsloMet - Oslo Metropolitan University, P.O. Box 4 St. Olavs plass, 0130 Oslo, Norway.
Karina Karlsen1Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046, Blindern, 0317 Oslo, Norway.
Shivaprakash J Mutt6Research Unit of Biomedicine, and Biocenter of Oulu, Oulu University Hospital and Medical Research Center Oulu, Oulu University, P.O Box 5000, 90014 Oulu, Finland.
Karl-Heinz Herzig6Research Unit of Biomedicine, and Biocenter of Oulu, Oulu University Hospital and Medical Research Center Oulu, Oulu University, P.O Box 5000, 90014 Oulu, Finland.
Inger Ottestad1Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046, Blindern, 0317 Oslo, Norway.
Stine M Ulven1Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046, Blindern, 0317 Oslo, Norway.ORCID 0000-0001-7986-4204
University of Oslo · NONorwegian University of Science and Technology · NOOsloMet – Oslo Metropolitan University · NOOslo University Hospital · NOOulu University Hospital · FIPoznan University of Medical Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdequate protein intake among older adults is associated with better health outcomes such as immune function and metabolic regulation of skeletal muscle, but conflicting results make it difficult to define the optimal intake. To further understand the impact of protein intake on metabolic processes, the aim of the study was to explore genome-wide gene expression changes in peripheral blood mononuclear cells (PBMCs) in home-dwelling old subjects after increased protein intake for 12 weeks.

methodIn a parallel double-blind randomized controlled intervention study, subjects (≥ 70 years) received a protein-enriched milk (2 × 20 g protein/day,

resultsIn total 758 gene transcripts were regulated after increased protein intake, and 649 gene transcripts were regulated after intake of carbohydrates (

conclusionsPBMCs can be used to study gene expression changes after long-term protein intake, as many signaling pathways were regulated after increased protein intake. The functional significance of these findings needs to be further investigated.

trial registrationClinicalTrials.gov, ID no. NCT02218333. The study was registered on August 18, 2014.

Indexed as

Dairy proteinIGF-1Immune functionOlder adultsPeripheral mononuclear cellsPOMCRandomized Controlled trialTranscriptomics

Identifiers

PMID31798754
PMCPMC6883584
OpenAlexW2990665987

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.