Evidence map›Paper›PMID 31798717›Full record

ArticleExperimental and therapeutic medicine2019

Reinforcing involvement of NK cells in psoriasiform dermatitis animal model.

Mihaela Surcel, Adriana Narcisa Munteanu, Radu-Ionuț Huică, Gheorghița Isvoranu, Ioana Ruxandra Pîrvu, Carolina Constantin, Ovidiu Bratu, Constantin Căruntu, Isadora Zaharescu, Lucica Sima and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Role of Innate Immune Cells in Psoriasis.International journal of molecular sciences · 2020
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Mihaela SurcelImmunobiology Laboratory, 'Victor Babes' National Institute of Pathology, 050096 Bucharest, Romania.
Adriana Narcisa MunteanuImmunobiology Laboratory, 'Victor Babes' National Institute of Pathology, 050096 Bucharest, Romania.
Radu-Ionuț HuicăDivision of Cellular and Molecular Biology and Histology, 'Carol Davila' University of Pharmacy and Medicine, 050474 Bucharest, Romania.
Gheorghița IsvoranuImmunobiology Laboratory, 'Victor Babes' National Institute of Pathology, 050096 Bucharest, Romania.
Ioana Ruxandra PîrvuImmunobiology Laboratory, 'Victor Babes' National Institute of Pathology, 050096 Bucharest, Romania.
Carolina ConstantinImmunobiology Laboratory, 'Victor Babes' National Institute of Pathology, 050096 Bucharest, Romania.
Ovidiu BratuDivision of Cellular and Molecular Biology and Histology, 'Carol Davila' University of Pharmacy and Medicine, 050474 Bucharest, Romania.
Constantin CăruntuDivision of Cellular and Molecular Biology and Histology, 'Carol Davila' University of Pharmacy and Medicine, 050474 Bucharest, Romania.
Isadora ZaharescuDoctoral School Medicine, Titu Maiorescu University, 040441 Bucharest, Romania.
Lucica SimaResearch Laboratory, Romvac Company S.A, 077190 Voluntari, Romania.
Marieta CostacheDoctoral School of Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania.
Monica NeaguImmunobiology Laboratory, 'Victor Babes' National Institute of Pathology, 050096 Bucharest, Romania.
Institutul National Victor Babes · ROCarol Davila University of Medicine and Pharmacy · ROTitu Maiorescu University · ROUniversity of Bucharest · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriasis (Ps) is a chronic inflammatory immune-mediated disease with skin and joint manifestations, characterized by abnormal and rapid proliferation of keratinocytes and infiltration of psoriatic lesions with immune cells. Extensive literature suggests that Ps is a T-cell mediated disease its pathogenesis being highly related to innate and adaptative immune cells. Although natural killer (NK) cells are involved in the inflammatory process of Ps through pro-inflammatory cytokine secretion (tumor necrosis factor α, interferon γ), their role in this pathology is not yet fully elucidated. In order to study the involvement of NK subpopulations in the pathogenesis of Ps we used the imiquimod-based mouse model of psoriasiform dermatitis and NK cells complex phenotype patterns from peripheral blood (PB) and spleen were investigated. Skin inflammation and the disease severity were assessed using

Indexed as

imiquimodinflammationNK cellspsoriasiform dermatitis

Identifiers

PMID31798717
PMCPMC6880363
OpenAlexW2970438175

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.