Evidence map›Paper›PMID 31798594›Full record

ArticleFrontiers in immunology2019

Macrophage Coordination of the Interferon Lambda Immune Response.

Scott A Read, Ratna Wijaya, Mehdi Ramezani-Moghadam, Enoch Tay, Steve Schibeci, Christopher Liddle, Vincent W T Lam, Lawrence Yuen, Mark W Douglas, David Booth and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 74 citations in OpenAlex.

  1. Article
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  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Macrophage heterogeneity in liver fibrosis.Frontiers in immunology · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Ly6CCell reports · 2024
    Article
  18. Article
  19. Review
  20. Interferon-λ3 rs12979860 can regulate inflammatory cytokines production in pulmonary fibrosis.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Scott A ReadBlacktown Medical School, Western Sydney University, Blacktown, NSW, Australia.
Ratna WijayaStorr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney and Westmead Hospital, Westmead, NSW, Australia.
Mehdi Ramezani-MoghadamStorr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney and Westmead Hospital, Westmead, NSW, Australia.
Enoch TayStorr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney and Westmead Hospital, Westmead, NSW, Australia.
Steve SchibeciCentre for Immunology and Allergy Research, The Westmead Institute for Medical Research, The University of Sydney and Westmead Hospital, Westmead, NSW, Australia.
Christopher LiddleStorr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney and Westmead Hospital, Westmead, NSW, Australia.
Vincent W T LamDepartment of Upper Gastrointestinal Surgery, Westmead Hospital, Westmead, NSW, Australia.
Lawrence YuenDepartment of Upper Gastrointestinal Surgery, Westmead Hospital, Westmead, NSW, Australia.
Mark W DouglasStorr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney and Westmead Hospital, Westmead, NSW, Australia.
David BoothCentre for Immunology and Allergy Research, The Westmead Institute for Medical Research, The University of Sydney and Westmead Hospital, Westmead, NSW, Australia.
Jacob GeorgeStorr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney and Westmead Hospital, Westmead, NSW, Australia.
Golo AhlenstielBlacktown Medical School, Western Sydney University, Blacktown, NSW, Australia.
The University of Sydney · AUWestmead Institute for Medical Research · AUWestmead Hospital · AUWestern Sydney University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lambda interferons (IFN-λs) are a major component of the innate immune defense to viruses, bacteria, and fungi. In human liver, IFN-λ not only drives antiviral responses, but also promotes inflammation and fibrosis in viral and non-viral diseases. Here we demonstrate that macrophages are primary responders to IFN-λ, uniquely positioned to bridge the gap between IFN-λ producing cells and lymphocyte populations that are not intrinsically responsive to IFN-λ. While CD14

Indexed as

Cell DegranulationCell DifferentiationCell MovementCells, CulturedHepatitis CHumansInterferon LambdaInterferonsInterleukinsKiller Cells, NaturalLiverMacrophagesMonocytesPhagocytosisInterferon Lambdainterferon-lambda, humanInterferonsInterleukinsinnate immunityinterferon lambdaKupfferlivermacrophage

Identifiers

PMID31798594
PMCPMC6878940
OpenAlexW2990693206

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.