ReviewFrontiers in endocrinology2019
A Brief History of Nutritional Rickets.
Review in Frontiers in endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 32 citations in OpenAlex.
- Performance of three large language models in answering parent-focused questions on rickets: a dual pediatric-orthopedic specialist evaluation.BMC pediatrics · 2026Article
- Cross-sectional comparative evaluation of five large language model-driven chatbots on an expert-curated 44-question set of parent-facing questions about pediatric vitamin D deficiency.Frontiers in pediatrics · 2026Article
- The impact of vitamin D on cancer: A mini review.The Journal of steroid biochemistry and molecular biology · 2023Review
- Vitamin D as a Nutri-Epigenetic Factor in Autoimmunity-A Review of Current Research and Reports on Vitamin D Deficiency in Autoimmune Diseases.Nutrients · 2022Review
- Rickets guidance: part II-management.Pediatric nephrology (Berlin, Germany) · 2022Article
- Practices of vitamin D supplementation leading to vitamin D toxicity: Experience from a Low-Middle Income Country.Annals of medicine and surgery (2012) · 2022Article
- Vitamin D, rickets and child abuse: controversies and evidence.Pediatric radiology · 2021Review
- Vitamin D Sources, Metabolism, and Deficiency: Available Compounds and Guidelines for Its Treatment.Metabolites · 2021Review
- Osteocytes but not osteoblasts directly build mineralized bone structures.International journal of biological sciences · 2021Article
- Vitamin D Update.Current dermatology reports · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since first described almost a century ago, vitamin D preparations have been successfully used as a public health intervention to prevent nutritional rickets. In this manuscript, we document the periods in history when nutritional rickets was described, examine early efforts to understand its etiology and the steps taken to treat and prevent it. We will also highlight that despite the wealth of historical data and multiple preventative strategies, nutritional rickets remains a significant public health disorder. Nutritional rickets has both skeletal and extraskeletal manifestations. While the skeletal manifestations are the most recognized features, it is the extraskeletal complications, hypocalcaemic seizure and cardiomyopathy that are the most devastating features and result in reported fatalities. Reviewing this history provides an opportunity to further promote recent global consensus recommendations for the prevention and management of nutritional rickets, as well as gain a greater understanding of the well-known public health measures that can be used to manage this entirely preventable disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.