ArticleFrontiers in physiology2019
Proteomic Markers of Non-functional Overreaching During the Race Across America (RAAM): A Case Study.
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- SAA4: An Underdog Within the Serum Amyloid a Superfamily?International journal of molecular sciences · 2026Review
- Molecular Biomarkers of Training Responses: A Systems Framework for Exercise Adaptation and Athlete Monitoring.International journal of molecular sciences · 2026Review
- Beet supplementation mitigates post-exercise inflammation.Frontiers in nutrition · 2024Article
- Blood-Based Biomarkers for Managing Workload in Athletes: Perspectives for Research on Emerging Biomarkers.Sports medicine (Auckland, N.Z.) · 2023Review
- Metabolomic and proteomic characterization of sng and pain phenotypes in fibromyalgia.European journal of pain (London, England) · 2022Article
- Review
- Exercise immunology: Future directions.Journal of sport and health science · 2020Review
- Proteomics-Based Detection of Immune Dysfunction in an Elite Adventure Athlete Trekking Across the Antarctica.Proteomes · 2020Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a previous study, proteomics procedures identified blood proteins as potential overreaching and overtraining biomarkers, and a targeted proteomics panel of 21 proteins was developed. PURPOSE: To measure targeted blood protein changes in an ultraendurance cyclist competing in RAAM.
methodsThe athlete underwent testing 4-week pre-RAAM and 4-day post-RAAM to determine body composition and aerobic capacity. During RAAM training distress score (TDS) and body mass were measured daily. Power output and heart rate (HR) were measured during cycling. Blood sampling for proteomic analysis occurred 4 weeks, 24, and 2 h before the start, twice per day of the race, and after 1 and 4 days recovery.
resultsThe athlete completed the 4941 km race in 10.1 days at a speed of 24.5 km/h with 20 total hours of sleep. TDS was very low, 1, pre-RAAM and increased to very high, 47, at the finish. Post-RAAM maximal aerobic capacity and HR were 6.3 and 5.7% lower (61.6 vs. 57.5 mL.kg
conclusionThe RAAM athlete exhibited non-functional overreaching symptoms including increased training distress and decreased work capacity. Proteomic analysis indicated large increases for immune-related proteins involved with complement activation and the acute phase response, which could be useful biomarkers for non-functional overreaching.
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