ArticleFrontiers in human neuroscience2019
Prediction and Mismatch Negativity Responses Reflect Impairments in Action Semantic Processing in Adults With Autism Spectrum Disorders.
Article in Frontiers in human neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Autism Spectrum Disorder and auditory sensory alterations: a systematic review on the integrity of cognitive and neuronal functions related to auditory processing.Journal of neural transmission (Vienna, Austria : 1996) · 2023Pooled it
- Prediction in Autism Spectrum Disorder: A Systematic Review of Empirical Evidence.Autism research : official journal of the International Society for Autism Research · 2021Pooled it
- Reduced Motor Preparation and Altered EEG Signatures of Prediction in Autistic Adults.The European journal of neuroscience · 2026Article
- Analysis of Task Demand Effects on Visual and Auditory Mismatch Negativity (MMN) Across Autistic and Schizotypal Traits.The European journal of neuroscience · 2026Article
- Multiple talker processing in autistic adult listeners.Scientific reports · 2024Article
- Predictive Brain Activity Shows Congruent Semantic Specificity in Language Comprehension and Production.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Reduced mismatch negativity in children and adolescents with autism spectrum disorder is associated with their impaired adaptive functioning.Autism research : official journal of the International Society for Autism Research · 2022Article
- Reduced Primacy Bias in Autism during Early Sensory Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Predictions built upon belongings.Frontiers in psychology · 2022Article
- Oscillatory entrainment mechanisms and anticipatory predictive processes in children with autism spectrum disorder.Journal of neurophysiology · 2021Article
- Interpersonal similarity of autistic traits predicts friendship quality.Social cognitive and affective neuroscience · 2021Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neurophysiological mechanisms underlying motor and language difficulties in autism spectrum disorders (ASD) are still largely unclear. The present work investigates biological indicators of sound processing, (action-) semantic understanding and predictive coding and their correlation with clinical symptoms of ASD. Twenty-two adults with high-functioning ASD and 25 typically developed (TD) participants engaged in an auditory, passive listening, Mismatch Negativity (MMN) task while high-density electroencephalography (EEG) was recorded. Action and non-action words were presented in the context of sounds, which were either semantically congruent with regard to the body part they relate to or semantically incongruent or unrelated. The anticipatory activity before sound onset, the Prediction Potential (PP), was significantly reduced in the ASD group specifically for action, but not for non-action sounds. The early-MMN-like responses to words (latency: 120 ms) were differentially modulated across groups: controls showed larger amplitudes for words in action-sound compared to non-action contexts, whereas ASD participants demonstrated enlarged early-MMN-like responses only in a pure tone context, with no other modulation dependent on action sound context. Late-MMN-like responses around 560 ms post-stimulus onset revealed body-part-congruent action-semantic priming for words in control participants, but not in the ASD group. Importantly, neurophysiological indices of semantic priming in ASD participants correlated with the extent of autistic traits as revealed by the Autism Spectrum Quotient (AQ). The data suggest that high-functioning adults with ASD show a specific deficit in semantic processing and predictive coding of sounds and words related to action, which is absent for neutral, non-action, sounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.