ReviewFrontiers in neuroscience2019
Bilingualism for Dementia: Neurological Mechanisms Associated With Functional and Structural Changes in the Brain.
Review in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Current Update on the Clinical Utility of MMSE and MoCA for Stroke Patients in Asia: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Bilingualism's protective effects in Alzheimer's disease: Mechanisms of resilience and resistance.medRxiv : the preprint server for health sciences · 2026Article
- The role of bilingualism on functional decline and neurodegeneration in distinct ADRD clinical syndromes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Cross-cultural adaptation of the Language and Social Background Questionnaire: Psychometric properties emerging from the Persian version.Behavior research methods · 2025Article
- Addressing language challenges in bilingual neuropsychological assessments at the South Texas Alzheimer's Disease Research Center (ADRC).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Article
- Complex Regulation of Protocadherin Epigenetics on Aging-Related Brain Health.medRxiv : the preprint server for health sciences · 2024Article
- Alzheimer's disease as a fundamental disease of information processing systems: An information theory perspective.Frontiers in neuroscience · 2023Review
- The neuroanatomical consequences and pathological implications of bilingualism.Journal of anatomy · 2022Review
- Lifelong bilingualism and mechanisms of neuroprotection in Alzheimer dementia.Human brain mapping · 2022Article
- Bilingualism, Dementia, and the Neurological Mechanisms in Between: The Need for a More Critical Look Into Dementia Subtypes.Frontiers in aging neuroscience · 2022Article
- Lifelong Bilingualism Functions as an Alternative Intervention for Cognitive Reserve Against Alzheimer's Disease.Frontiers in psychiatry · 2021Review
- An Overview of Cognitive Reserve in Aging Based on Keyword Network Analysis.Inquiry : a journal of medical care organization, provision and financingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the number of older adults increases, the prevalence of dementias, such as Alzheimer's dementia (AD), vascular dementia, dementia with Lewy bodies, and frontotemporal dementias, also increases. Despite research into pharmacological approaches for treating diverse diseases, there is still no cure. Recently, novel non-pharmacological interventions are attracting attention. Non-pharmacological approaches include cognitive stimulation, alterations in diet, physical activity, and social engagement. Cognitive stimulating activities protect against the negative effects of cognitive decline caused by age-related neurogenerative diseases. Bilingualism is one form of cognitive stimulation that requires multiple aspects of brain activity and has been shown to delay the onset of dementia symptoms in patients by approximately 4-5 years as compared with monolingual patients through cognitive reserve. The purpose of this review was to bilingualism protects against cognitive decline associated with AD and other dementias. We discuss potential underlying neurological mechanisms, including: (1) stimulating adult neurogenesis, (2) enhancing synaptogenesis, (3) strengthening functional connectivity that bilingualism may delay clinical AD symptoms, (4) protecting white matter integrity, and (5) preserving gray matter density.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.