ArticleEuropean journal of ageing2019
Association of non-exercise physical activity in mid- and late-life with cognitive trajectories and the impact of APOE ε4 genotype status: the Mayo Clinic Study of Aging.
Article in European journal of ageing, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06734286 (CogMed Intervention Targeting Working Memory in Patients with Mild Cognitive Impairment), which is not on this map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
CogMed Intervention Targeting Working Memory in Patients with Mild Cognitive Impairment
Who cites it
6 citing papers in PubMed.
- Development of Modified Japanese Versions of Questionnaires to Assess Physical and Cognitively Stimulating Activities.JMA journal · 2025Article
- Impact of physical activity on disability-free and disabled life expectancies in middle-aged and older adults: Data from the healthy aging longitudinal study in Taiwan.Geriatrics & gerontology international · 2024Article
- Exercise modulates APOE expression in brain cortex of female APOE3 and APOE4 targeted replacement mice.Neuropeptides · 2023Article
- Association between physical activity and longitudinal change in body mass index in middle-aged and older adults.BMC public health · 2023Article
- APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases.Molecular neurodegeneration · 2022Review
- The effects of substance use and physical activity on cognition: The impact of incongruent health behaviors.Drug and alcohol dependence · 2021Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
In this study derived from the population-based Mayo Clinic Study of Aging, we investigated whether non-exercise physical activity (PA) was associated with global and domain-specific cognitive trajectories (memory, language, visuospatial skills, attention) and whether the association differed by apolipoprotein E (APOE) ε4 genotype status. We included 2061 community-dwelling individuals aged ≥ 70 years (50.5% males, 26.7% APOE ε4 carriers) who were cognitively unimpaired at baseline and on whom serial cognitive data and self-reported information on non-exercise PA were available. We specifically inquired about non-exercise PA carried out at two time points, i.e., midlife (between 50 and 65 years of age) and late-life (within 1 year prior to assessment) and three intensity levels, i.e., light (e.g., laundry), moderate (e.g., scrubbing floors) and heavy (e.g., hard manual labor). Linear mixed-effect models revealed that engaging in midlife PA of moderate or heavy intensity was associated with significantly less-pronounced decline of
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Registered trials
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