ArticleClinical medicine insights. Reproductive health2019
Setting Up a Cryopreservation Programme for Immature Testicular Tissue: Lessons Learned After More Than 15 Years of Experience.
Article in Clinical medicine insights. Reproductive health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Fertility preservation in prepubertal boys: management and follow-up challenges.Endocrine connections · 2026Review
- Pubertal Development Following Paediatric Gonadotoxic Treatment and Immature Testicular Tissue Banking.International journal of molecular sciences · 2026Article
- Article
- Views of male childhood cancer survivors on fertility preservation and restoration.Reproduction & fertility · 2025Article
- Fertility Preservation in Pediatric Oncology: A 10-Year Single-Center Experience in Northern Spain.Journal of clinical medicine · 2025Article
- The effect of epididymosomes on the development of frozen-thawed mouse spermatogonial stem cells after culture in a decellularized testicular scaffold and transplantation into azoospermic mice.Journal of assisted reproduction and genetics · 2024Article
- A 20-year overview of fertility preservation in boys: new insights gained through a comprehensive international survey.Human reproduction open · 2024Article
- The Role of Promyelocytic Leukemia Zinc Finger (PLZF) and Glial-Derived Neurotrophic Factor Family Receptor Alpha 1 (GFRα1) in the Cryopreservation of Spermatogonia Stem Cells.International journal of molecular sciences · 2023Review
- Autologous Human Mesenchymal Stem Cell-Based Therapy in Infertility: New Strategies and Future Perspectives.Biology · 2023Review
- Spermatogenesis after gonadotoxic childhood treatment: follow-up of 12 patients.Human reproduction open · 2023Article
- Article
- Male fertility preservation and restoration strategies for patients undergoing gonadotoxic therapies†.Biology of reproduction · 2022Review
- Organotypic Culture of Testicular Tissue from Infant Boys with Cryptorchidism.International journal of molecular sciences · 2022Article
- Fertility after Curative Therapy for Sickle Cell Disease: A Comprehensive Review to Guide Care.Journal of clinical medicine · 2022Review
- Establishment of a controlled slow freezing-based approach for experimental clinical cryopreservation of human prepubertal testicular tissues.F&S reports · 2022Article
- Characterization and Survival of Human Infant Testicular Cells After Direct Xenotransplantation.Frontiers in endocrinology · 2022Article
- Strategies for cryopreservation of testicular cells and tissues in cancer and genetic diseases.Cell and tissue research · 2021Review
- Spermatogonial Stem Cell Culture in Oncofertility.The Urologic clinics of North America · 2020Review
- Fertility preservation in boys: recent developments and new insightsHuman reproduction open · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Young boys undergoing gonadotoxic treatments are at high risk of spermatogonial stem cell (SSC) loss and fertility problems later in life. Stem cell loss can also occur in specific genetic conditions, eg, Klinefelter syndrome (KS). Before puberty, these boys do not yet produce sperm. Hence, they cannot benefit from sperm banking. An emerging alternative is the freezing of testicular tissue aiming to preserve the SSCs for eventual autologous transplantation or in vitro maturation at adult age. Many fertility preservation programmes include cryopreservation of immature testicular tissue, although the restoration procedures are still under development. Until the end of 2018, the Universitair Ziekenhuis Brussel has frozen testicular tissues of 112 patients between 8 months and 18 years of age. Testicular tissue was removed in view of gonadotoxic cancer treatment (35%), gonadotoxic conditioning therapy for bone marrow transplantation (35%) or in boys diagnosed with KS (30%). So far, none of these boys had their testicular tissue transplanted back. This article summarizes our experience with cryopreservation of immature testicular tissue over the past 16 years (2002-2018) and describes the key issues for setting up a cryopreservation programme for immature testicular tissue as a means to safeguard the future fertility of boys at high risk of SSC loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.