ArticleNature communications2019
Brassinosteroid signaling delimits root gravitropism via sorting of the Arabidopsis PIN2 auxin transporter.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 114 citations in OpenAlex.
- Arabidopsis ECHIDNA Plays an Important Role in Auxin Regulation of Clathrin-Mediated Trafficking During Root Gravitropism.Plant, cell & environment · 2026Article
- The alterations of the synthetic pathway and metabolic flux of auxin indole-3-acetic acid govern thermotolerance inMicrobiology spectrum · 2026Article
- Progestogens and androgens influence root morphology of angiosperms in a brassinosteroid-independent manner.The Plant journal : for cell and molecular biology · 2025Article
- Exploring plant responses to altered gravity for advancing space agriculture.Plant communications · 2025Review
- Computational modeling of plant root development: the art and the science.The New phytologist · 2025Review
- Understanding the Brassinosteroid-Dependent Environmental Adaption in Brassicaceae Plants.Plants (Basel, Switzerland) · 2025Review
- Root expansion microscopy: A robust method for super resolution imaging in Arabidopsis.The Plant cell · 2025Article
- Reduced RG-II pectin dimerization disrupts differential growth by attenuating hormonal regulation.Science advances · 2025Article
- Enhancement of wheat resistance to dry-hot wind stress during grain filling by 24-epibrassinolide: optimization of hormone balance and improvement of flag leaf photosynthetic performance.Frontiers in plant science · 2025Article
- Over 25 years of decrypting PIN-mediated plant development.Nature communications · 2024Review
- Polarly localized Bro1 domain proteins regulate PIN-FORMED abundance and root gravitropic growth in Arabidopsis.Communications biology · 2024Article
- Molecular mechanism of brassinosteroids involved in root gravity response based on transcriptome analysis.BMC plant biology · 2024Article
- Understanding role of roots in plant response to drought: Way forward to climate-resilient crops.The plant genome · 2024Review
- Article
- Dynamic GOLVEN-ROOT GROWTH FACTOR 1 INSENSITIVE signaling in the root cap mediates root gravitropism.Plant physiology · 2023Article
- Mapping the signaling network of BIN2 kinase using TurboID-mediated biotin labeling and phosphoproteomics.The Plant cell · 2023Article
- Brassinosteroids is involved in methane-induced adventitious root formation via inducing cell wall relaxation in marigold.BMC plant biology · 2023Article
- Transcriptomic analysis of Chinese yam (Frontiers in nutrition · 2023Article
- Recent insights into metabolic and signalling events of directional root growth regulation and its implications for sustainable crop production systems.Frontiers in plant science · 2023Review
- Adenosine monophosphate deaminase modulates BIN2 activity through hydrogen peroxide-induced oligomerization.The Plant cell · 2022Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Arabidopsis PIN2 protein directs transport of the phytohormone auxin from the root tip into the root elongation zone. Variation in hormone transport, which depends on a delicate interplay between PIN2 sorting to and from polar plasma membrane domains, determines root growth. By employing a constitutively degraded version of PIN2, we identify brassinolides as antagonists of PIN2 endocytosis. This response does not require de novo protein synthesis, but involves early events in canonical brassinolide signaling. Brassinolide-controlled adjustments in PIN2 sorting and intracellular distribution governs formation of a lateral PIN2 gradient in gravistimulated roots, coinciding with adjustments in auxin signaling and directional root growth. Strikingly, simulations indicate that PIN2 gradient formation is no prerequisite for root bending but rather dampens asymmetric auxin flow and signaling. Crosstalk between brassinolide signaling and endocytic PIN2 sorting, thus, appears essential for determining the rate of gravity-induced root curvature via attenuation of differential cell elongation.
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