ArticleHealth & place2019
Associations between neighborhood built environment and cognition vary by apolipoprotein E genotype: Multi-Ethnic Study of Atherosclerosis.
Article in Health & place, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Effects of neighborhood built environment on cognitive function in older adults: a systematic review.BMC geriatrics · 2024Pooled it
- Effect of Environment on the Cognition of Older Adults: A Narrative Review.Brain sciences · 2026Review
- Mixtures of key components of the external exposome in association with MRI biomarkers of brain structure: Multi-Ethnic Study of Atherosclerosis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Integrating contextual determinants and polygenic risk to examine dementia and late-life cognition in the Multi-Ethnic Study of Atherosclerosis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Recognizing Structural and Social Determinants of Health in the Diagnosis and Care of Dementia.Dementia (London, England) · 2026Article
- Article
- Air pollution and cognitive performance in late life: the role of lipid profile - results from the Multi-Ethnic Study of Atherosclerosis (MESA).Environment international · 2025Article
- Multi-Ancestry Transcriptome-Wide Association Studies of Cognitive Function, White Matter Hyperintensity, and Alzheimer's Disease.International journal of molecular sciences · 2025Article
- Built environment factors and their impacts on outdoor walking activity among people living with dementia: a spatial analysis approach.Frontiers in public health · 2025Article
- Midlife Residential Greenness and Late-Life Cognitive Decline among Nurses' Health Study Participants.Environmental health perspectives · 2024Article
- Invited Perspective: More Greenspace, Less Cognitive Decline? Current Evidence and Future Directions.Environmental health perspectives · 2024Article
- Spatial scale effects on associations between built environment and cognitive function: Multi-Ethnic Study of Atherosclerosis.Health & place · 2024Article
- Structural and social determinants of health: The multi-ethnic study of atherosclerosis.PloS one · 2024Article
- Neighborhood 'Disamenities': local barriers and cognitive function among Black and white aging adults.BMC public health · 2023Article
- Cognability: An Ecological Theory of neighborhoods and cognitive aging.Social science & medicine (1982) · 2022Article
- Establishing a Framework for Gathering Structural and Social Determinants of Health in Alzheimer's Disease Research Centers.The Gerontologist · 2022Article
- Residential Green Space and Cognitive Function in a Large Cohort of Middle-Aged Women.JAMA network open · 2022Article
- Neighborhood characteristics and dementia symptomology among community-dwelling older adults with Alzheimer's disease.Frontiers in aging neuroscience · 2022Article
- Neighborhood-Based Socioeconomic Determinants of Cognitive Impairment in Zambian Children With HIV: A Quantitative Geographic Information Systems Approach.Journal of the Pediatric Infectious Diseases Society · 2021Article
- Can Neighborhood Social Infrastructure Modify Cognitive Function? A Mixed-Methods Study of Urban-Dwelling Aging Americans.Journal of aging and health · 2021Article
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
We examined whether neighborhood built environment (BE) and cognition associations in older adults vary by apolipoprotein E (APOE) genotype, a genetic risk factor for Alzheimer's disease (AD). We conducted a cross-sectional analysis of 4091 participants. Neighborhood characteristics included social and walking destination density (SDD, WDD), intersection density, and proportion of land dedicated to retail. Individuals were categorized as APOE ε2 (lower AD risk), APOE ε4 (higher AD risk), or APOE ε3 carriers. Among APOE ε2 carriers, greater proportion of land dedicated to retail was associated with better global cognition, and greater SDD, WDD, intersection density, and proportion of land dedicated to retail was associated with better processing speed. These associations were not observed in APOE ε3 or ε4 carriers. APOE ε2 carriers may be more susceptible to the potentially beneficial effects of denser neighborhood BEs on cognition; however, longitudinal studies are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.