Evidence map›Paper›PMID 31797704›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2020

Screening of benzenesulfonamide in combination with chemically diverse fragments against carbonic anhydrase by differential scanning fluorimetry.

Mikhail Krasavin, Stanislav Kalinin, Sergey Zozulya, Anastasiia Gryniukova, Petro Borysko, Andrea Angeli, Claudiu T Supuran

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mikhail KrasavinInstitute of Chemistry, Saint Petersburg State University, Saint Petersburg, Russian Federation.
Stanislav KalininInstitute of Chemistry, Saint Petersburg State University, Saint Petersburg, Russian Federation.
Sergey ZozulyaEnamine Ltd, Kyiv, Ukraine.
Anastasiia GryniukovaEnamine Ltd, Kyiv, Ukraine.
Petro BoryskoEnamine Ltd, Kyiv, Ukraine.
Andrea AngeliNeurofarba Department, Universita degli Studi di Firenze, Florence, Italy.ORCID http://orcid.org/0000-0002-1470-7192
Claudiu T SupuranNeurofarba Department, Universita degli Studi di Firenze, Florence, Italy.ORCID http://orcid.org/0000-0003-4262-0323

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The differential scanning fluorimetry (DSF) screening of 5.692 fragments in combination with benzenesulfonamide (BSA) against bovine carbonic anhydrase (

Indexed as

FluorometryBenzenesulfonamidesCarbonic Anhydrase IICarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbonic AnhydrasesDrug Evaluation, PreclinicalHumansMolecular StructureSulfonamidesBenzenesulfonamidesCarbonic Anhydrase IICarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbonic Anhydrasescarbonic anhydrase XIISulfonamidescarbonic anhydrase IIDifferential scanning fluorimetryfragment-based drug discoveryprimary sulphonamideprotein affinitythermal shift assayzinc binding group

Identifiers

PMID31797704
PMCPMC6896451

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.