Evidence map›Paper›PMID 31797618›Full record

ArticlePacific Symposium on Biocomputing. Pacific Symposium on Biocomputing2020

Tree-Weighting for Multi-Study Ensemble Learners.

Maya Ramchandran, Prasad Patil, Giovanni Parmigiani

Abstract read
In one paragraph

Article in Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maya RamchandranDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA, maya_ramchandran@g.harvard.edu.
Prasad Patil
Giovanni Parmigiani

Funding

VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI JENNIFER W MACK · 1985 to 2026
$330.6M
Training Grant in Quantitative Sciences for Cancer ResearchT32CA009337 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI QUACKENBUSH, JOHN, TRIPPA, LORENZO · 1986 to 2025
$12.3M
NCI NIH HHS P30 CA006516NCI NIH HHS T32 CA009337
6 · The paper itself

Abstract

Multi-study learning uses multiple training studies, separately trains classifiers on each, and forms an ensemble with weights rewarding members with better cross-study prediction ability. This article considers novel weighting approaches for constructing tree-based ensemble learners in this setting. Using Random Forests as a single-study learner, we compare weighting each forest to form the ensemble, to extracting the individual trees trained by each Random Forest and weighting them directly. We find that incorporating multiple layers of ensembling in the training process by weighting trees increases the robustness of the resulting predictor. Furthermore, we explore how ensembling weights correspond to tree structure, to shed light on the features that determine whether weighting trees directly is advantageous. Finally, we apply our approach to genomic datasets and show that weighting trees improves upon the basic multi-study learning paradigm. Code and supplementary material are available at https://github.com/m-ramchandran/tree-weighting.

Indexed as

Computational BiologyGenomicsHumans

Identifiers

PMID31797618
PMCPMC6980320

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.