Evidence map›Paper›PMID 31797593›Full record

ArticlePacific Symposium on Biocomputing. Pacific Symposium on Biocomputing2020

Obtaining dual-energy computed tomography (CT) information from a single-energy CT image for quantitative imaging analysis of living subjects by using deep learning.

Wei Zhao, Tianling Lv, Rena Lee, Yang Chen, Lei Xing

Abstract read
In one paragraph

Article in Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Image synthesis of effective atomic number images using a deep convolutional neural network-based generative adversarial network.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wei ZhaoDepartment of Radiation Oncology, Stanford University, Palo Alto, CA 94306, USA.
Tianling Lv
Rena Lee
Yang Chen
Lei Xing

Funding

Dual Modality X-ray Luminescence CT for in vivo Cancer ImagingR01CA227713 · NCI · STANFORD UNIVERSITY · PI XING, LEI · 2019 to 2023
$2.9M
Radioluminescence dosimetry solution for precision radiation therapyR01CA223667 · NCI · STANFORD UNIVERSITY · PI XING, LEI · 2018 to 2022
$2.4M
DASSIM-RT and Compressed Sensing-Based Inverse PlanningR01CA176553 · NCI · STANFORD UNIVERSITY · PI XING, LEI · 2014 to 2018
$2.4M
NCI NIH HHS R01 CA176553NCI NIH HHS R01 CA223667NCI NIH HHS R01 CA227713
6 · The paper itself

Abstract

Computed tomographic (CT) is a fundamental imaging modality to generate cross-sectional views of internal anatomy in a living subject or interrogate material composition of an object, and it has been routinely used in clinical applications and nondestructive testing. In a standard CT image, pixels having the same Hounsfield Units (HU) can correspond to different materials, and it is therefore challenging to differentiate and quantify materials. Dual-energy CT (DECT) is desirable to differentiate multiple materials, but the costly DECT scanners are not widely available as single-energy CT (SECT) scanners. Recent advancement in deep learning provides an enabling tool to map images between different modalities with incorporated prior knowledge. Here we develop a deep learning approach to perform DECT imaging by using the standard SECT data. The end point of the approach is a model capable of providing the high-energy CT image for a given input low-energy CT image. The feasibility of the deep learning-based DECT imaging method using a SECT data is demonstrated using contrast-enhanced DECT images and evaluated using clinical relevant indexes. This work opens new opportunities for numerous DECT clinical applications with a standard SECT data and may enable significantly simplified hardware design, scanning dose and image cost reduction for future DECT systems.

Indexed as

Deep LearningComputational BiologyCross-Sectional StudiesHumansTomography, X-Ray Computed

Identifiers

PMID31797593
PMCPMC6938283

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.