ArticleJournal of clinical laboratory analysis2020
Pre-miR-27a rs895819 polymorphism and risk of diffuse large B-cell lymphoma.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Correlation Between miR-27a-3p Polymorphisms and Peri-Implantitis Susceptibility: A Case-Control Study.International dental journal · 2025Article
- Article
- Genetic Variation in miR-27a Is Associated with Fluoropyrimidine-Associated Toxicity in Patients with Dihydropyrimidine Dehydrogenase Variants after Genotype-Guided Dose Reduction.International journal of molecular sciences · 2023Article
- Association between HOTAIR Polymorphisms and Lymphoma.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- The association of miR-27a rs895819 polymorphism with colorectal cancer risk in Chinese population.Journal of clinical laboratory analysis · 2020Article
- Pre-miR-27a rs895819 polymorphism and risk of diffuse large B-cell lymphoma.Journal of clinical laboratory analysis · 2020Article
Corrections and comments
- Erratum issuedCorrigendum.2022
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundRecently, several studies have investigated the relationship between Pre-miR-27a rs895819 polymorphism and risk of various cancers. However, the relationship between rs895819 and diffuse large B-cell lymphoma (DLBCL) has not been well known.
methodsIn this study, we conducted a case-control study to explore the role of Pre-miR-27a rs895819 in risk of DLBCL. The PCR-TaqMan and luciferase assays and in vitro experiments were used to evaluate polymorphism function.
resultsAs a result, we found subjects carrying with rs895819 AG/GG genotype had a significantly decreased risk when compared with those carrying the AA genotype. Further qPCR assay showed that the DLBCL patients carrying AG/GG genotypes showed a lower level of mature miR-27a when compared with patients carrying AA genotype. Moreover, miR-27a levels were upregulated in DLBCL tissues compared with normal lymphoid tissues. Further in vitro experiments showed that miR-27a might function as an oncogene through target TGFBR1. In addition, TGFBR1 overexpression rescues effects of miR-27a inhibitor on DLBCL cells phenotypes.
conclusionsIn conclusion, these findings indicate that rs895819 A > G might reduce the expression of mature miR-27a, and leading a higher level of TGFBR1, ultimately inhibiting the development of DLBCL.
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Registered trials
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