ArticleEating and weight disorders : EWD2021
Gait strategy and body composition in patients with Prader-Willi syndrome.
Article in Eating and weight disorders : EWD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Investigation of Gait Characteristics and Kinematic Deviations in Rare Genetic Disorders with Instrumented Gait Analysis.Journal of intellectual disability research : JIDR · 2025Article
- Bone mineral density and its relationship with ground reaction force characteristics during gait in young adults with Prader-Willi Syndrome.Bone reports · 2023Article
- Differences in spinal postures and mobility among adults with Prader-Willi syndrome, essential obesity, and normal-weight individuals.Frontiers in endocrinology · 2023Article
- Body composition and obstructive sleep apnoea assessment in adult patients with Prader-Willi syndrome: a case control study.Journal of endocrinological investigation · 2022Article
- Cerebellar Dysfunction in Adults with Prader Willi Syndrome.Journal of clinical medicine · 2021Article
- Relationship between gait profile score and clinical assessments of gait in post-stroke patients.Journal of rehabilitation medicine · 2021Article
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Authors and funding
8 authors.
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Abstract
purposeIndividuals with Prader-Willi syndrome (PWS) exhibit reduced lean body mass and increased fat-lean mass ratio when compared with individuals of normal weight and obese ones. Thus, research on the association of functional limitations during gait and body composition may be of great importance from a rehabilitative viewpoint. In particular, the aim of this study was to compare the gait profile of persons with PWS to that of unaffected individuals and to see if a relationship exists between gait profile and body composition in individuals with PWS.
methodsEighteen individuals with PWS and 20 unaffected individuals (Healthy Group: HG) were assessed. Their gait pattern was quantified with 3D-Gait Analysis (3D-GA). Overall body weight, lean and fat masses were measured by dual-energy X-ray absorptiometry.
resultsIndividuals with PWS were found to be characterized by a significantly different (p < 0.05) gait pattern with respect to healthy controls in terms of both kinematic and kinetic parameters. No correlations were found between kinematic parameters and overall mass and lean/fat mass, while some parameters associated with ground reaction force were found to be significantly correlated with overall mass, lean mass and fat mass. Significant regression models were obtained, including impact and propulsive force and loading rate.
conclusionOur data suggest that in individuals with PWS, gait is influenced by the overall and lean body mass. Thus, therapeutic strategies should target both weight reduction and lean mass increase to optimize gait, minimize articular stress, and reduce the risk of repetitive strain on the lower limbs. LEVEL OF EVIDENCE: Level III: Case-control analytic study.
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