ArticleMolecular neurobiology2020
Manganese Acts upon Insulin/IGF Receptors to Phosphorylate AKT and Increase Glucose Uptake in Huntington's Disease Cells.
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Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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0cells of the map it votes in
27citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
What it found
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Who cites it
27 citing papers in PubMed, 30 citations in OpenAlex.
- Manganese availability determines insulin sensitivity by enhancing Akt activity.bioRxiv : the preprint server for biology · 2026Article
- Modulatory Effects of Essential Trace Elements on Glycemic Biomarkers in Toxic Metal-Induced Associated Diabetes.Biological trace element research · 2026Article
- Persistent effects of pre-differentiation manganese exposure on adipogenesis and metabolic function in differentiated 3T3-L1 adipocyte cells.Journal of hazardous materials advances · 2026Article
- Emergent latent neurotoxic effects of manganese following nominal chronic exposures in human stem cell and Caenorhabditis elegans models.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Protein kinases in neurodegenerative diseases: current understandings and implications for drug discovery.Signal transduction and targeted therapy · 2025Review
- Role of manganese in brain health and disease: Focus on oxidative stress.Free radical biology & medicine · 2025Review
- Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases.Signal transduction and targeted therapy · 2025Review
- Mechanisms and Applications of Manganese-Based Nanomaterials in Tumor Diagnosis and Therapy.Biomaterials research · 2025Review
- Review
- The Link between Trace Metal Elements and Glucose Metabolism: Evidence from Zinc, Copper, Iron, and Manganese-Mediated Metabolic Regulation.Metabolites · 2023Review
- IGF/mTORC1/S6 Signaling Is Potentiated and Prolonged by Acute Loading of Subtoxicological Manganese Ion.Biomolecules · 2023Article
- Defective Mitochondrial Dynamics and Protein Degradation Pathways Underlie Cadmium-Induced Neurotoxicity and Cell Death in Huntington's Disease Striatal Cells.International journal of molecular sciences · 2023Article
- The metallic compound promotes primordial follicle activation and ameliorates fertility deficits in aged mice.Theranostics · 2023Article
- BTBD9 attenuates manganese-induced oxidative stress and neurotoxicity by regulating insulin growth factor signaling pathway.Human molecular genetics · 2022Article
- Exposing the role of metals in neurological disorders: a focus on manganese.Trends in molecular medicine · 2022Review
- YAC128 mouse model of Huntington disease is protected against subtle chronic manganese (Mn)-induced behavioral and neuropathological changes.Neurotoxicology · 2021Article
- Glucose metabolic crosstalk and regulation in brain function and diseases.Progress in neurobiology · 2021Review
- Regulation of GH and GH Signaling by Nutrients.Cells · 2021Review
- Evaluating the risk of manganese-induced neurotoxicity of parenteral nutrition: review of the current literature.Expert opinion on drug metabolism & toxicology · 2021Review
- Molecular Targets of Manganese-Induced Neurotoxicity: A Five-Year Update.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Miles R BryanDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Kristen D NordhamDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Daniel I R RoseDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Michael T O'BrienDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Piyush JoshiDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Audra M FoshageDepartment of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, USA.
Filipe M GonçalvesAlbert Einstein College of Medicine, Bronx, NY, USA.
Rachana NitinDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Michael A UhouseDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Michael AschnerAlbert Einstein College of Medicine, Bronx, NY, USA.
Aaron B BowmanDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. bowma117@purdue.edu.ORCID http://orcid.org/0000-0001-8728-3346
Vanderbilt University Medical Center · USAlbert Einstein College of Medicine · USPurdue University West Lafayette · US
Funding
TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGYT32ES007028 · NIEHS · VANDERBILT UNIVERSITY · PI F PETER Guengerich, Fiona Edith Harrison · 1985 to 2026
$15.7MMechanisms of Manganese NeurotoxicityR01ES010563 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Michael Aschner, Aaron B Bowman · 2001 to 2026
$11.9MGene-Neurotoxicant Interactions in Huntington DiseaseR01ES016931 · NIEHS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BOWMAN, AARON B · 2008 to 2018
$4.5MElucidating a role for Mn-dependent IGF/insulin biology and autophagy in Huntington's disease pathologyF31ES028084 · NIEHS · VANDERBILT UNIVERSITY · PI BRYAN, MILES RICHARD · 2018 to 2019
$49kNIEHS NIH HHS ES010563NIEHS NIH HHS ES016931NIEHS NIH HHS ES028084NIEHS NIH HHS F31 ES028084NIEHS NIH HHS R01 ES010563NIEHS NIH HHS R01 ES016931NIEHS NIH HHS T32 ES007028
Abstract
Perturbations in insulin/IGF signaling and manganese (Mn
Indexed as
AnimalsBiological TransportGlucoseHuntington DiseaseInsulin-Like Growth Factor IPhosphorylationProto-Oncogene Proteins c-aktRatsReceptor, IGF Type 1Receptor, InsulinSignal TransductionGlucoseInsulin-Like Growth Factor IProto-Oncogene Proteins c-aktReceptor, IGF Type 1Receptor, InsulinHuntington’s Disease CellsInsulin/IGF ReceptorsManganese
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.