Evidence map›Paper›PMID 31797321›Full record

ReviewJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2020

Hybrid PET/MR imaging in myocardial inflammation post-myocardial infarction.

B Wilk, G Wisenberg, R Dharmakumar, J D Thiessen, D E Goldhawk, F S Prato

Abstract readReview
In one paragraph

Review in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Mouse Cardiovascular Imaging.Current protocols · 2024
    Review
  5. Protective Effects of 2-Methoxyestradiol on Acute Isoproterenol-Induced Cardiac Injury in Rats.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
    Article
  6. Review
  7. Article
  8. Simultaneous measurements of myocardial glucose metabolism and extracellular volumes with hybrid PET/MRI using concurrent injections of Gd-DTPA and [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  9. Article
  10. Deciphering post-infarct inflammation: Should it heal, would it hurt?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Article
  11. Article
  12. PET imaging of macrophages in cardiovascular diseases.American journal of translational research · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

B WilkDepartment of Medical Imaging, Western University, London, Canada. bwilk@uwo.ca.
G WisenbergDepartment of Medical Imaging, Western University, London, Canada.
R DharmakumarBiomedical Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
J D ThiessenDepartment of Medical Imaging, Western University, London, Canada.
D E GoldhawkDepartment of Medical Imaging, Western University, London, Canada.
F S PratoDepartment of Medical Imaging, Western University, London, Canada.

Funding

Strategic inhibition of EGFR-family signaling using novel peptidomimetic inhibitors of HER-2 for the treatment of osteosarcomaP20GM135000 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI CHAMCHEU, JEAN CHRISTOPHER · 2021 to 2025
$11.3M
Developing a MRI-guided Disease-Modifying Therapy for Post Infarction Chronic Heart FailureR01HL133407 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Rohan Dharmakumar · 2017 to 2026
$4.9M
An Accurate Non-Contrast-Enhanced Cardiac MRI Method for Imaging Chronic Myocardial Infarctions: Technical Developments to Rapid Clinical ValidationR01HL136578 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI LI, DEBIAO · 2017 to 2020
$3.4M
Mechanistic Insights to A Translatable Therapy for Acute Reperfused Hemorrhagic Myocardial InfarctionsR01HL147133 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI DHARMAKUMAR, ROHAN, FRANCIS, JOSEPH · 2020 to 2023
$3.2M
Accurate, Needle-Free, MRI-based Detection of Ischemic Heart Disease without Contrast AgentsR01HL148788 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI DHARMAKUMAR, ROHAN · 2020 to 2023
$3.0M
NHLBI NIH HHS R01 HL133407NHLBI NIH HHS R01 HL136578NHLBI NIH HHS R01 HL147133NHLBI NIH HHS R01 HL148788NIGMS NIH HHS P20 GM135000
6 · The paper itself

Abstract

Hybrid PET/MR imaging is an emerging imaging modality combining positron emission tomography (PET) and magnetic resonance imaging (MRI) in the same system. Since the introduction of clinical PET/MRI in 2011, it has had some impact (e.g., imaging the components of inflammation in myocardial infarction), but its role could be much greater. Many opportunities remain unexplored and will be highlighted in this review. The inflammatory process post-myocardial infarction has many facets at a cellular level which may affect the outcome of the patient, specifically the effects on adverse left ventricular remodeling, and ultimately prognosis. The goal of inflammation imaging is to track the process non-invasively and quantitatively to determine the best therapeutic options for intervention and to monitor those therapies. While PET and MRI, acquired separately, can image aspects of inflammation, hybrid PET/MRI has the potential to advance imaging of myocardial inflammation. This review contains a description of hybrid PET/MRI, its application to inflammation imaging in myocardial infarction and the challenges, constraints, and opportunities in designing data collection protocols. Finally, this review explores opportunities in PET/MRI: improved registration, partial volume correction, machine learning, new approaches in the development of PET and MRI pulse sequences, and the use of novel injection strategies.

Indexed as

InflammationAnimalsBlood Flow VelocityDisease Models, AnimalDogsEdemaFluorodeoxyglucose F18HeartHumansMachine LearningMacrophagesMagnetic Resonance ImagingMultimodal ImagingMyocardial InfarctionMyocarditisPositron-Emission TomographyFluorodeoxyglucose F18hybrid imaginginflammationMRIMyocardial biologymyocardial ischemia and infarctionPET

Identifiers

PMID31797321
PMCPMC7391987

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.