ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2021
The additive prognostic value of coronary calcium score (CCS) to single photon emission computed tomography myocardial perfusion imaging (SPECT-MPI)-real world data from a single center.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Hidden risk in normal myocardial perfusion scans: AI-detected proximal coronary calcium on CT attenuation maps improves prognosis.European journal of nuclear medicine and molecular imaging · 2026Article
- Diagnostic reference level, achievable dose, and effective dose estimation in adult hybrid SPECT myocardial perfusion imaging in Institut Jantung Negara.Scientific reports · 2025Article
- Combined evaluation of CAC score and myocardial perfusion imaging in patients at risk of cardiovascular disease: where are we and what do the data say.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Review
- Tales from the future-nuclear cardio-oncology, from prediction to diagnosis and monitoring.European heart journal. Cardiovascular Imaging · 2023Review
- The impact of coronary calcium score as an addition to myocardial perfusion imaging in altering clinical management (ICCAMPA trial).Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Transient ischaemic dilation ratio thresholds in patients with zero coronary calcium score undergoing exercise or dipyridamole stress SPECT myocardial perfusion imaging using a cadmium-zinc-telluride camera.European heart journal. Imaging methods and practice · 2023Article
- Myocardial perfusion imaging and CAC score: Not only a brick in the wall.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Cardiac imaging for the assessment of patients being evaluated for kidney transplantation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Review
- Relationship Among Coronary Artery Calcium Score, Myocardial Perfusion SPECT and Risk Stratification of Coronary Artery Disease.Annals of nuclear cardiology · 2022Review
- Myocardial perfusion imaging and coronary calcium score: A marriage made in heaven.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Utilising combined MPI and CACS results.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Is SPECT LVEF assessment more accurate than CT at higher heart rates? More evidence for complementary information in multimodality imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
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Authors and funding
11 authors.
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Abstract
aimsSingle-photon emission computed tomography myocardial perfusion imaging [SPECT-MPI] is a functional test for coronary ischemia. We aimed to assess the additive prognostic value of coronary calcium score (CCS) to SPECT-MPI in stable patients.
methodsThis study is a retrospective analysis of 655 patients who underwent SPECT-MPI with CCS (2012 to 2017). Receiver operator characteristic (ROC) identified CCS cutoff value for all-cause mortality: CCS+ if > cutoff value and MPI+ if ≥ 5% total perfusion defect (TPD). Patients were divided into 1 MPI-/CCS-; 2 MPI+/CCS-; 3 MPI-/CCS+; 4 MPI+/CCS+ and compared. Cox proportional hazard analysis identified predictors of mortality.
resultsCCS cutoff for all-cause mortality was > 216 (C statistic 0.756, P < 0.0001). In MPI+ groups, mean TPD was similar (13.4% and 13.1% respectively) but mortality was higher in the CCS+ (12.5% vs. 4.8%, P = 0.22) as was the severe LV systolic dysfunction (8.0% vs. 0%, P = 0.095). In MPI- groups, mean TPD was similar (0.7% and 0.9% respectively) but all-cause mortality was higher in the CCS+ (10.7% vs. 1.6%, P < 0.0001) as was severe LVSD (2.9 % vs. 0.3% P = 0.016). Age, smoking, renal impairment ,and CCS > 216 were independent predictors of mortality.
conclusionsPatients with raised CCS on SPECT-MPI have increased mortality and poor LV function despite a negative MPI.
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