Evidence map›Paper›PMID 31797191›Full record

ArticleActa parasitologica2020

Effectiveness of Repeated Administration of Praziquantel with Disodium Glycyrrhizinate and Two Enantiomers of Praziquantel on Opisthorchis felineus (Rivolta, 1884).

D F Avgustinovich, M A Tsyganov, M Y Pakharukova, E N Chulakov, A V Dushkin, V P Krasnov, V A Mordvinov

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Acta parasitologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

D F AvgustinovichInstitute of Cytology and Genetics (ICG), Siberian Branch of Russian Academy of Sciences (SB RAS), Prospekt Lavrentyeva 10, Novosibirsk, 630090, Russian Federation. avgust@bionet.nsc.ru.ORCID http://orcid.org/0000-0003-2462-3520
M A TsyganovInstitute of Cytology and Genetics (ICG), Siberian Branch of Russian Academy of Sciences (SB RAS), Prospekt Lavrentyeva 10, Novosibirsk, 630090, Russian Federation.
M Y PakharukovaInstitute of Cytology and Genetics (ICG), Siberian Branch of Russian Academy of Sciences (SB RAS), Prospekt Lavrentyeva 10, Novosibirsk, 630090, Russian Federation.
E N ChulakovPostovsky Institute of Organic Synthesis, Ural Branch of Russian Academy of Sciences (UB RAS), S. Kovalevskoy Str. 22/Academic Str. 20, Ekaterinburg, 620990, Russian Federation.
A V DushkinInstitute of Solid State Chemistry and Mechanochemistry, SB RAS, Kutateladze Str. 18, Novosibirsk, 630128, Russian Federation.
V P KrasnovPostovsky Institute of Organic Synthesis, Ural Branch of Russian Academy of Sciences (UB RAS), S. Kovalevskoy Str. 22/Academic Str. 20, Ekaterinburg, 620990, Russian Federation.
V A MordvinovInstitute of Cytology and Genetics (ICG), Siberian Branch of Russian Academy of Sciences (SB RAS), Prospekt Lavrentyeva 10, Novosibirsk, 630090, Russian Federation. mordvin@bionet.nsc.ru.
Institute of Cytology and Genetics · RUInstitute of Organic Synthesis · RUInstitute of Solid State Chemistry and Mechanochemistry · RUNovosibirsk State University · RU

Funding

Russian Foundation for Basic Research 17-43-540175State assignment for the Postovsky Institute of Organic Synthesis AAAA-A19-119011790134-1State project of the ICG SB RAS 0324-2019-0041
6 · The paper itself

Abstract

backgroundNowadays, it is still important to develop effective anti-opisthorchiasis agents. In this work, we tested a complex of praziquantel (PZQ) with a plant origin compound-disodium glycyrrhizinate-in the ratio 1:10 PZQ:Na

methodsWorms extracted from the hamsters were subjected to various regimens of administration of the complex: once a day for 3 days or three times within 1 day. Moreover, mature maritae and juvenile worms of O. felineus were subjected to the comparison the anthelmintic effectiveness of racemic-PZQ, (R)-PZQ, and (S)-PZQ.

resultsThe O. felineus maritae that received PZQ:Na

conclusionThese findings suggest that the development of a supramolecular complex of (R)-PZQ with disodium glycyrrhizinate and administration of this complex three times within 1 day are promising approaches.

Indexed as

AnimalsAnthelminticsCricetinaeGlycyrrhizic AcidLife Cycle StagesOpisthorchisPraziquantelStereoisomerismAnthelminticsGlycyrrhizic AcidPraziquantelDisodium glycyrrhizinateOpisthorchis felineusPraziquantel(R)-PZQ and (S)-PZQ

Identifiers

PMID31797191
OpenAlexW2992565994

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.