Evidence map›Paper›PMID 31797147›Full record

ArticleStem cell reviews and reports2020

High Canonical Wnt/β-Catenin Activity Sensitizes Murine Hematopoietic Stem and Progenitor Cells to DNA Damage.

Yiting Wang, Hui Cui, Si Tao, Ting Zeng, Jianying Wu, Zhendong Tao, Liu Zhang, Bing Zou, Zhiyang Chen, George B Garside and 1 more

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In one paragraph

Article in Stem cell reviews and reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yiting WangDepartment of Hematology, The Second Affiliated Hospital of Nanchang University, Min-De Road. 1, Nanchang City, 330006, Jiangxi Province, China.
Hui CuiJiangxi Key Laboratory of Clinical and Translational Cancer Research, Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Si TaoJiangxi Key Laboratory of Clinical and Translational Cancer Research, Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Ting ZengJiangxi Key Laboratory of Clinical and Translational Cancer Research, Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Jianying WuJiangxi Key Laboratory of Clinical and Translational Cancer Research, Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Zhendong TaoDepartment of Medical Laboratory Medicine, Jiangxi Province Hospital of Integrated Chinese & Western Medicine, Nanchang, Jiangxi, China.
Liu ZhangIntensive Care Unit, Peking University People's Hospital, Beijing, China.
Bing ZouJiangxi Key Laboratory of Clinical and Translational Cancer Research, Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Zhiyang ChenKey Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China.
George B GarsideLeibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany.
Duozhuang TangDepartment of Hematology, The Second Affiliated Hospital of Nanchang University, Min-De Road. 1, Nanchang City, 330006, Jiangxi Province, China. ndefy11234@ncu.edu.cn.ORCID 0000-0002-7725-205X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is characterized by the accumulation of DNA damage and a decrease in stem cell functionality, yet molecular mechanisms that limit the maintenance of stem cells in response to DNA damage remain to be delineated. Here we show in mouse models that DNA damage leads to a transient over-activation of Wnt signaling in hematopoietic stem cells (HSCs), and that high activity of canonical Wnt/β-catenin signaling sensitizes HSCs to DNA damage induced by X-irradiation which results in preferential maintenance of HSCs with low levels of Wnt signaling. The study shows that genetic or chemical activation of canonical Wnt signaling enhances radiosensitivity of HSCs while inhibition of Wnt signaling decreases it. Together, these results indicate that levels of Wnt signaling activity mediate heterogeneity in the sensitivity of HSCs to DNA damage induced depletion. These findings could be relevant for molecular alterations and selection of stem cells in the context of DNA damage accumulation during aging and cancer formation.

Indexed as

AgingAnimalsbeta CateninCell ProliferationDNA DamageHematopoietic Stem CellsHematopoietic Stem Cell TransplantationHumansMiceNeoplasmsRadiation ToleranceStem CellsWnt ProteinsWnt Signaling PathwayX-Raysbeta CateninCTNNB1 protein, mouseWnt ProteinsDNA damageHematopoietic progenitor cellsHematopoietic stem cellsWnt

Identifiers

PMID31797147
PMCPMC6987068

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.