Evidence map›Paper›PMID 31797098›Full record

ArticleInternational journal of colorectal disease2020

Implementation of liposomal bupivacaine transversus abdominis plane blocks into the colorectal enhanced recovery after surgery protocol: a natural experiment.

Adam C Fields, Scott G Weiner, Luisa J Maldonado, Paul M Cavallaro, Nelya Melnitchouk, Joel Goldberg, Matthias F Stopfkuchen-Evans, Olesya Baker, Liliana G Bordeianou, Ronald Bleday

2 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in International journal of colorectal disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05224089 phase4recruitingnot on this mapstarted 2022, after this paper: background citation

Bilateral Mid-Abdominal Transverse Abdominis Plane and Rectus Sheath Blocks Comparing The Use of Liposomal Bupivacaine/Bupivacaine vs. Regular Bupivacaine in Laparoscopic Colectomy Procedures.

TypeinterventionalSponsorHartford HospitalRan2022 to 2026Enrolled114ConditionsBowel DiseaseArmsLiposomal Bupivicaine/Bupivacaine Admixture, Bupivacaine HCL
NCT05262569 completednot on this mapstarted 2022, after this paper: background citation

Increased Postoperative Opioid Use is a Risk Factor for an Ileus After Laparoscopic Colorectal Surgery---A Case Control Study

TypeobservationalSponsorPeking University People's HospitalRan2022 to 2022Enrolled596ConditionsIleus, Opioid UseArmsileus
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Observational
  7. Review
  8. State-of-the-art colorectal disease: postoperative ileus.International journal of colorectal disease · 2021
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Adam C FieldsDivision of Colorectal Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. acfields@partners.org.ORCID http://orcid.org/0000-0001-9029-7044
Scott G WeinerDepartment of Emergency Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Luisa J MaldonadoDivision of Colorectal Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Paul M CavallaroDivision of Colorectal Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Nelya MelnitchoukDivision of Colorectal Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Joel GoldbergDivision of Colorectal Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Matthias F Stopfkuchen-EvansDepartment of Anesthesia, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Olesya BakerDepartment of Emergency Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Liliana G BordeianouDivision of Colorectal Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ronald BledayDivision of Colorectal Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. rbleday@bwh.harvard.edu.
Brigham and Women's Hospital · USHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEnhanced recovery after surgery (ERAS) programs are now standard of care for colorectal surgery. Efforts have been aimed at decreasing postoperative opioid consumption. The goal of this study is to evaluate the effect of liposomal bupivacaine transversus abdominis plane (TAP) blocks on opioid use and its downstream effect on rates of ileus and hospital length of stay (LOS).

methodsWe performed a retrospective pre- and postintervention time-trend analysis (2016-2018) of ERAS patients undergoing laparoscopic colorectal surgery at two academic medical centers within the same hospital system. The intervention was liposomal bupivacaine TAP blocks versus standard local infiltration with bupivacaine with a primary outcome of total morphine milligram equivalents (MME) administered within 72 h of surgery. Secondary outcomes included hospital LOS and rate of postoperative ileus.

resultsThere were 556 patients included at the control hospital, and 384 patients were included at the treatment hospital. Patients at both hospitals were similar with regard to age, body mass index, comorbidities, and surgical indication. In an adjusted time-trend analysis, the treatment hospital was associated with a significant decrease in MME administered (- 15.9 mg, p = 0.04) and hospital LOS (- 0.8 days, p < 0.001). There was no significant decrease in the rate of ileus at the treatment hospital (- 6.9%, p = 0.08).

conclusionsIn a time-trend analysis, the addition of liposomal bupivacaine TAP blocks into the ERAS protocol resulted in significantly reduced opioid use and shorter hospital LOS for patients undergoing surgery at the treatment hospital. Liposomal bupivacaine TAP blocks should be considered for inclusion in the standard ERAS protocol.

Indexed as

Colorectal SurgeryEnhanced Recovery After SurgeryAbdominal MusclesAgedBupivacaineFemaleHumansLength of StayLiposomesMaleMiddle AgedMorphineTime FactorsBupivacaineLiposomesMorphineColectomyEnhanced recovery after surgeryLiposomal bupivacaineTransversus abdominis plane block

Identifiers

PMID31797098
OpenAlexW2994196387

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.