ArticleMolecular psychiatry2021
Genetic risk for major depressive disorder and loneliness in sex-specific associations with coronary artery disease.
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Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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37citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 5% of its field
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
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Corrections and comments
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Authors and funding
22 authors at 6 institutions in 2 countries.
Jessica DennisDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Julia SealockDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Rebecca T LevinsonVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Eric Farber-EgerVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
Jacob FrancoDivision of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Sarah FongDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-0900-5505
Peter StraubDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Donald HucksDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Wen-Liang SongDivision of Cardiovascular Medicine, Departmesnt of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
MacRae F LintonDivision of Cardiovascular Medicine, Departmesnt of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Pierre Fontanillas23andMe, Inc., Mountain View, CA, USA.
Sarah L Elson23andMe, Inc., Mountain View, CA, USA.
Douglas RuderferDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Abdel AbdellaouiDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
Sandra Sanchez-RoigeDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Abraham A PalmerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-3634-0747
Dorret I BoomsmaNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7099-7972
Nancy J CoxDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Guanhua ChenDepartment of Biostatistics and Medical lnformatics, University of Wisconsin-Madison, Madison, WI, USA.
Jonathan D MosleyDepartments of Medicine and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-6421-2887
Quinn S WellsDivision of Cardiovascular Medicine, Departmesnt of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Lea K DavisDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. lea.k.davis@vumc.org.
Vanderbilt University Medical Center · US23andMe (United States) · USUniversity of California San Diego · USAmsterdam University Medical Centers · NLGGD Amsterdam · NLUniversity of Wisconsin–Madison · US
Funding
University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9MVANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MInstitutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2MSequencing CoreP50DA037844 · NIDA · UNIVERSITY OF CHICAGO · PI PALMER, ABRAHAM A · 2014 to 2023
$27.4MNon-coding RNA & Bioinformatics CoreP01HL116263 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI VICKERS, KASEY C · 2014 to 2025
$24.7MTraining and Mentoring CoreU54MD010722 · NIMHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILKINS, CONSUELO HOPKINS · 2016 to 2020
$11.9MInterdisciplinary Research Fellowship in NeuroAIDSR25MH081482 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MARIANA CHERNER · 2007 to 2026
$5.2MAnalysis, Validation and Resource Creation for Genome Sequencing of Complex DiseasesU01HG009086 · NHGRI · VANDERBILT UNIVERSITY · PI COX, NANCY J, LI, BINGSHAN · 2016 to 2020
$4.3MDiscovering Biology for Neuropsychiatric Diseases Through Omics Studies on ComorbiditiesR01MH113362 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COX, NANCY J, KNAPIK, ELA W · 2017 to 2021
$3.9MSocial Regulation of Gene Expression, SupplementR37AG033590 · NIA · UNIVERSITY OF CHICAGO · PI CACIOPPO, JOHN T. · 2010 to 2017
$3.5MPsycheMERGE: Leveraging electronic health records and genomics for mental health researchR01MH118233 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DAVIS, LEA K, SMOLLER, JORDAN W · 2019 to 2022
$3.1MAmerican Heart Association-American Stroke Association 16FTF30130005NCATS NIH HHS UL1 TR000427NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002373NCRR NIH HHS UL1 RR024975NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01 HG009086NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS K08 HL145075NHLBI NIH HHS P01 HL116263NHLBI NIH HHS R01 HL127173NHLBI NIH HHS R01 HL140074NHLBI NIH HHS R01 HL159204NIA NIH HHS R01 AG033590NIA NIH HHS R37 AG033590NIDA NIH HHS P50 DA037844NIH HHS S10 OD025092NIMHD NIH HHS U54 MD010722NIMH NIH HHS R01 MH113362NIMH NIH HHS R01 MH118233NIMH NIH HHS R25 MH081482NIMH NIH HHS R56 MH120736
Abstract
Major depressive disorder (MDD) and loneliness are phenotypically and genetically correlated with coronary artery disease (CAD), but whether these associations are explained by pleiotropic genetic variants or shared comorbidities is unclear. To tease apart these scenarios, we first assessed the medical morbidity pattern associated with genetic risk factors for MDD and loneliness by conducting a phenome-wide association study in 18,385 European-ancestry individuals in the Vanderbilt University Medical Center biobank, BioVU. Polygenic scores for MDD and loneliness were developed for each person using previously published meta-GWAS summary statistics, and were tested for association with 882 clinical diagnoses ascertained via billing codes in electronic health records. We discovered strong associations with heart disease diagnoses, and next embarked on targeted analyses of CAD in 3893 cases and 4197 controls. We found odds ratios of 1.11 (95% CI, 1.04-1.18; P 8.43 × 10
Indexed as
Coronary Artery DiseaseMajor Depressive DisorderFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLonelinessMaleMultifactorial InheritanceRisk Factors
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