Evidence map›Paper›PMID 31796876›Full record

ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2020

Validation of the International Tumor Budding Consensus Conference (ITBCC) 2016 recommendation in squamous cell carcinoma of the lung-a single-center analysis of 354 cases.

Christina Neppl, Inti Zlobec, Ralph A Schmid, Sabina Berezowska

Abstract readValidation Study
PubMed Publisher
In one paragraph

Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Prognostic Value of Selected Histologic Features for Lung Squamous Cell Carcinoma.Exploratory research and hypothesis in medicine · 2022
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Tumour budding in solid cancers.Nature reviews. Clinical oncology · 2021
    Review
  18. Prognostic impact of tumor budding in endometrial carcinoma within distinct molecular subgroups.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christina NepplInstitute of Pathology, University of Bern, Murtenstrasse 31, 3010, Bern, Switzerland.
Inti ZlobecInstitute of Pathology, University of Bern, Murtenstrasse 31, 3010, Bern, Switzerland.
Ralph A SchmidDivision of General Thoracic Surgery, Inselspital University Hospital Bern, Bern, Switzerland.
Sabina BerezowskaInstitute of Pathology, University of Bern, Murtenstrasse 31, 3010, Bern, Switzerland. sabina.berezowska@pathology.unibe.ch.ORCID http://orcid.org/0000-0001-5442-9791

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are no universally accepted grading systems in pulmonary squamous cell carcinoma (pSQCC). Recently, tumor budding, cell nest size, and spread through airspaces (STAS) have been proposed as grading scheme candidates. Tumor budding is a well-established independent prognostic factor in colorectal cancer. The International Tumor Budding Consensus Conference (ITBCC) provided consensus on scoring in 2016, albeit for colorectal cancers. Here, we aimed to validate the ITBCC method in pSQCC and evaluate additional proposed grading parameters. We analyzed a fully clinico-pathologically annotated Western single-center cohort of 354 consecutive primary resected pSQCC (resected 2000-2013). Patients with SQCC of other organs were excluded to reliably exclude lung metastases. We assessed conventional grading, keratinization, STAS, and tumor budding according to ITBCC recommendations, and correlated them with clinico-pathological parameters and survival. Tumor budding was low (0-4 buds/0.785 mm

Indexed as

Carcinoma, Squamous CellLung NeoplasmsNeoplasm GradingAdultAgedAged, 80 and overConsensus Statements as TopicFemaleHumansMaleMiddle AgedRetrospective Studies

Identifiers

PMID31796876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.