ArticleScientific reports2019
Acquisition of fluoroquinolone resistance leads to increased biofilm formation and pathogenicity in Campylobacter jejuni.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Virulence and Antimicrobial Resistance inAntibiotics (Basel, Switzerland) · 2026Review
- An invasive phenotype induced by relaxation of DNA supercoiling inMicrobiology (Reading, England) · 2025Article
- Biofilm Resilience: Molecular Mechanisms Driving Antibiotic Resistance in Clinical Contexts.Biology · 2025Review
- Small worms big discoveries:Frontiers in cellular and infection microbiology · 2025Review
- Foodborne bacterial pathogens: genome-based approaches for enduring and emerging threats in a complex and changing world.Nature reviews. Microbiology · 2024Review
- Genetic Diversity, Virulence, and Antibiotic Resistance Determinants ofPathogens (Basel, Switzerland) · 2024Article
- Fluoroquinolone-resistantJAC-antimicrobial resistance · 2024Article
- Biofilms as Battlefield Armor for Bacteria against Antibiotics: Challenges and Combating Strategies.Microorganisms · 2023Review
- Monitoring within-farm transmission dynamics of antimicrobial-resistant Campylobacter in dairy cattle using broth microdilution and long-read whole genome sequencing.Scientific reports · 2023Article
- Different stages of the infection cycle are enriched forMicrobiology (Reading, England) · 2023Article
- The Missing Pieces: The Role of Secretion Systems inBiomolecules · 2023Review
- Relevance and Importance of Biofilms in the Resistance and Spreading of Campylobacter spp. Within the Food Chain.Advances in experimental medicine and biology · 2023Article
- Antimicrobial Resistance Challenged with Platinum(II) and Palladium(II) Complexes Containing 1,10-Phenanthroline and 5-Amino-1,3,4-Thiadiazole-2(3H)-Thione inAntibiotics (Basel, Switzerland) · 2022Article
- Emerging patterns of fluoroquinolone resistance inMicrobial genomics · 2022Article
- Virulence Profiling, Multidrug Resistance and Molecular Mechanisms ofAntibiotics (Basel, Switzerland) · 2022Article
- Genomic Screening of Antimicrobial Resistance Markers in UK and USAntimicrobial agents and chemotherapy · 2022Article
- The bile salt deoxycholate inducesFrontiers in microbiology · 2022Article
- Role played by the environment in the emergence and spread of antimicrobial resistance (AMR) through the food chain.EFSA journal. European Food Safety Authority · 2021Article
- A novel high-content screening approach for the elucidation of C. jejuni biofilm composition and integrity.BMC microbiology · 2021Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The World Health Organization has listed C. jejuni as one of 12 microorganisms on a global priority list for antibiotic resistance due to a rapid increase in strains resistant to fluoroquinolone antibiotics. This fluoroquinolone resistance is conferred through a single point mutation in the QRDR region within the gyrA gene known to be involved in DNA supercoiling. We have previously revealed that changes in DNA supercoilikng play a major role in the regulation of virulence in C. jejuni with relaxation of DNA supercoiling associated with increased attachment to and invasion of human epithelial cells. The aim of this study was to investigate whether fluoroquinolone resistant strains of C. jejuni displayed altered supercoiling associated phenotypes. A panel of fluoroquinolone resistant mutants were derived and shown to have a greater ability to form viable biofilms under aerobic conditions, invade epithelial cells and promote virulence in the Galleria mellonella model of infection. We thus report for the first time that fluoroquinolone resistance in C. jejuni is associated with an increase in virulence and the ability to form viable biofilms in oxygen rich environments. These altered phenotypes likely play a critical role in the continued increase in fluoroquinolone resistance observed for this important pathogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.