ArticleScientific reports2019
Air pollution significantly associated with severe ocular allergic inflammatory diseases.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Impact of particulate matter and air pollution on ocular surface disease: A systematic review of preclinical and clinical evidence.The ocular surface · 2025Pooled it
- Safety and efficacy of a novel 0.5% epinastine topical eyelid cream in allergic conjunctivitis: a phase 3 trial.Japanese journal of ophthalmology · 2024Trial
- Air Pollution, Pollen, and Indoor Exposures in Allergic Conjunctivitis: A Systematic Review.Life (Basel, Switzerland) · 2026Review
- Long-term exposure to PMBMC ophthalmology · 2026Article
- Time-series analysis of pollen concentration effects on allergic conjunctivitis healthcare visits in Beijing, 2023-2024.Frontiers in public health · 2026Article
- Models Estimating the Effects of Changes in the Concentration of Specific Climatic Pollutants and Temperature on the Prevalence of Acute Ophthalmic Inflammatory Conditions: A Retrospective Cross-Sectional Observational Study.Journal of ophthalmology · 2026Article
- Ocular Allergy Within the Framework of the EAACI Nomenclature of Allergic Diseases and Hypersensitivity Reactions.Allergy, asthma & immunology research · 2026Review
- Weather, Air Pollution, and Seasonality: Predictors of Pathogen-Associated Conjunctivitis Outbreaks in Kathmandu Valley, Nepal.The American journal of tropical medicine and hygiene · 2025Article
- Wildfire Smoke Induces Eye Surface Inflammation and Tear Film Changes in a Human Experimental Model.Translational vision science & technology · 2025Article
- Decoding Allergic Conjunctivitis: Latest Perspectives on Etiological Drivers and Immunopathological Mechanisms.Clinical reviews in allergy & immunology · 2025Review
- Article
- Effect of air pollution on online medical consultations for ocular surface diseases in China.Frontiers in public health · 2025Article
- PMToxicology and applied pharmacology · 2024Article
- JACQLQ subjective symptom questionnaire score and clinical test results for patients with allergic conjunctival disease.Scientific reports · 2024Article
- Long-term effects of air pollution on daily outpatient visits for allergic conjunctivitis from 2013 to 2020: a time-series study in Urumqi, China.Frontiers in public health · 2024Article
- Allergen-specific IgE in the tear fluid of Chinese patients with common allergic conjunctivitis in autumn and winter.International ophthalmology · 2023Article
- A nerve-goblet cell association promotes allergic conjunctivitis through rapid antigen passage.JCI insight · 2023Article
- Impact of Exposomes on Ocular Surface Diseases.International journal of molecular sciences · 2023Review
- Air Pollution and Meteorological Conditions Significantly Associated With Vernal Keratoconjunctivitis Exacerbations.Investigative ophthalmology & visual science · 2023Article
- Toxic External Exposure Leading to Ocular Surface Injury.Vision (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 13 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ambient air pollution is a well-recognized risk for various diseases including asthma and heart diseases. However, it remains unclear whether air pollution may also be a risk of ocular allergic diseases. Using a web-based, nation-wide, cross-sectional study design, we examined whether the level of ambient air pollution is significantly associated with the prevalence of ocular allergic diseases. A web-based questionnaire was posted to invite the participants who are members of the Japan Ophthalmologist Association and their family members. The answers from 3004 respondents were used to determine whether there were significant associations between the level of the pollutants and the prevalence of ocular allergic diseases. The study period was between March to May 2017. The data of the air pollutants during 2012 to 2016 were obtained from the National Institute for Environmental Studies. The prevalence of allergic diseases was calculated by post stratification and examined for significant associations with the level of pollutants using multiple logistic regression analyses. The prevalence of seasonal allergic conjunctivitis, perennial allergic conjunctivitis, atopic keratoconjunctivitis (AKC), and vernal keratoconjunctivitis (VKC) in Japan was 45.4%, 14.0%, 5.3%, and 1.2%, respectively. The high prevalence of the severe forms of allergic conjunctivitis, including AKC and VKC, were significantly associated with the levels of the air pollutants. The prevalence of AKC was significantly associated with the levels of NO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.